Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study

Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study

Abstract Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administere...

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Bibliographic Details
Main Authors: Thomas Olsen, Amany Elshorbagy, Emma Stolt, Anders Åsberg, Hasse K. Zaré, Nasser E. Bastani, Helga Refsum, Kjetil Retterstøl, Kathrine J. Vinknes
Format: Article
Language:English
Published: Springer 2024-06-01
Series:Amino Acids
Subjects:
Mesna
Total cysteine
Overweight
Obesity
Amino acid profile
3-methylhistidine
Online Access:https://doi.org/10.1007/s00726-024-03398-2
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