Prognostic value of procalcitonin in acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis.
<h4>Aims</h4>To evaluate the prognostic role of procalcitonin(PCT) on all-cause mortality in acute exacerbation of chronic obstructive pulmonary disease (AECOPD).<h4>Methods</h4>Database including PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were sea...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0312099 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841533072685662208 |
|---|---|
| author | Pang Qiyuan Lin Changyang Li Gaigai Qiu Ju Zhou Xun |
| author_facet | Pang Qiyuan Lin Changyang Li Gaigai Qiu Ju Zhou Xun |
| author_sort | Pang Qiyuan |
| collection | DOAJ |
| description | <h4>Aims</h4>To evaluate the prognostic role of procalcitonin(PCT) on all-cause mortality in acute exacerbation of chronic obstructive pulmonary disease (AECOPD).<h4>Methods</h4>Database including PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched to find relevant trials. We included studies with patients hospitalized for AECOPD, which assessed procalcitonin levels and reported on the association between procalcitonin and mortality..<h4>Results</h4>Fourteen trials involving 2983 patients were included. We found PCT levels in patients hospitalized for AECOPD are not associated with increased risk of mortality (RR 1.03, 95%CI 0.99-1.08). However, subgroup analysis showed PCT levels are indeed associated with an increased risk of mortality in mild to moderate AECOPD(RR 1.74, 95%CI 1.11-2.73). Deceased patients had significantly higher PCT levels, compared to survivors (MD 0.61, 95%CI 0.30-0.92). In PCT positive group, there was a significant increase in all-cause mortality(OR 3.21, 95%CI 1.84-5.61).<h4>Conclusions</h4>Results from this meta-analysis suggest that procalcitonin levels at the time of hospital admission for mild to moderate AECOPD are positively correlated with mortality. |
| format | Article |
| id | doaj-art-27c743b549394e749762a1d7cc3d4b11 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-27c743b549394e749762a1d7cc3d4b112025-01-17T05:31:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031209910.1371/journal.pone.0312099Prognostic value of procalcitonin in acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis.Pang QiyuanLin ChangyangLi GaigaiQiu JuZhou Xun<h4>Aims</h4>To evaluate the prognostic role of procalcitonin(PCT) on all-cause mortality in acute exacerbation of chronic obstructive pulmonary disease (AECOPD).<h4>Methods</h4>Database including PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched to find relevant trials. We included studies with patients hospitalized for AECOPD, which assessed procalcitonin levels and reported on the association between procalcitonin and mortality..<h4>Results</h4>Fourteen trials involving 2983 patients were included. We found PCT levels in patients hospitalized for AECOPD are not associated with increased risk of mortality (RR 1.03, 95%CI 0.99-1.08). However, subgroup analysis showed PCT levels are indeed associated with an increased risk of mortality in mild to moderate AECOPD(RR 1.74, 95%CI 1.11-2.73). Deceased patients had significantly higher PCT levels, compared to survivors (MD 0.61, 95%CI 0.30-0.92). In PCT positive group, there was a significant increase in all-cause mortality(OR 3.21, 95%CI 1.84-5.61).<h4>Conclusions</h4>Results from this meta-analysis suggest that procalcitonin levels at the time of hospital admission for mild to moderate AECOPD are positively correlated with mortality.https://doi.org/10.1371/journal.pone.0312099 |
| spellingShingle | Pang Qiyuan Lin Changyang Li Gaigai Qiu Ju Zhou Xun Prognostic value of procalcitonin in acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis. PLoS ONE |
| title | Prognostic value of procalcitonin in acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis. |
| title_full | Prognostic value of procalcitonin in acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis. |
| title_fullStr | Prognostic value of procalcitonin in acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis. |
| title_full_unstemmed | Prognostic value of procalcitonin in acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis. |
| title_short | Prognostic value of procalcitonin in acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis. |
| title_sort | prognostic value of procalcitonin in acute exacerbation of chronic obstructive pulmonary disease a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0312099 |
| work_keys_str_mv | AT pangqiyuan prognosticvalueofprocalcitonininacuteexacerbationofchronicobstructivepulmonarydiseaseasystematicreviewandmetaanalysis AT linchangyang prognosticvalueofprocalcitonininacuteexacerbationofchronicobstructivepulmonarydiseaseasystematicreviewandmetaanalysis AT ligaigai prognosticvalueofprocalcitonininacuteexacerbationofchronicobstructivepulmonarydiseaseasystematicreviewandmetaanalysis AT qiuju prognosticvalueofprocalcitonininacuteexacerbationofchronicobstructivepulmonarydiseaseasystematicreviewandmetaanalysis AT zhouxun prognosticvalueofprocalcitonininacuteexacerbationofchronicobstructivepulmonarydiseaseasystematicreviewandmetaanalysis |