Exploring the efficacy of (R)-PFI-2 hydrochloride in mitigating noise-induced hearing loss by targeting NLRP3 inflammasome and NF-κB pathway to reduce inner ear inflammation

Exploring the efficacy of (R)-PFI-2 hydrochloride in mitigating noise-induced hearing loss by targeting NLRP3 inflammasome and NF-κB pathway to reduce inner ear inflammation

Noise-induced hearing loss (NIHL) is primarily driven by inflammatory processes within the cochlea, where noise exposure triggers the activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, leading to an inflammatory cascade. The interaction between increased NLRP3 expression and NF-κB a...

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Bibliographic Details
Main Authors: Dawei Ren, Xuemin Chen, Hongdong Liu, Menghua Li, Liting Zheng, Pan Yong, Mohe Huang, Xi Shi, Yice Xu, Shujin Chen, Yan Zhang, Wei Zhu
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Journal of Otology
Subjects:
NIHL
(R)-PFI-2 hydrochloride
NLRP3
NF-κB
SETD7
Online Access:http://www.sciencedirect.com/science/article/pii/S1672293024000370
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