HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo
Genetic predisposition to celiac disease (CD) is strongly associated with the presence of HLA alleles in the individual genotype encoding HLA-DQ2 and/or HLA-DQ8 heterodimers. The main aim of this study was to analyze the HLA-A, -B, -DRB1, and -DQ allele and five-locus haplotype frequencies in 60 Alb...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/7369014 |
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| author | Atifete Ramosaj-Morina Marija Burek Kamenaric Mehmedali Azemi Lidvana Spahiu Zorana Grubic Renata Zunec |
| author_facet | Atifete Ramosaj-Morina Marija Burek Kamenaric Mehmedali Azemi Lidvana Spahiu Zorana Grubic Renata Zunec |
| author_sort | Atifete Ramosaj-Morina |
| collection | DOAJ |
| description | Genetic predisposition to celiac disease (CD) is strongly associated with the presence of HLA alleles in the individual genotype encoding HLA-DQ2 and/or HLA-DQ8 heterodimers. The main aim of this study was to analyze the HLA-A, -B, -DRB1, and -DQ allele and five-locus haplotype frequencies in 60 Albanian pediatric CD patients and 124 non-CD children from Kosovo. The most prevalent haplotype in patients was the ancestral AH 8.1 haplotype present in 22.5% of the cases compared to 2.8% of the controls (P<0.0001). Additionally, two other haplotypes were also overrepresented in patients (HLA-A∗02~B∗50~DRB1∗07~DQA1∗02:01~DQB1∗02:02 and HLA-A∗68~B∗44~DRB1∗07~DQA1∗02:01~DQB1∗02:02). Analysis showed that 95.0% of CD patients and 43.3% of controls were carriers of HLA-DQ2 and/or HLA-DQ8 heterodimers. The most frequent CD-predisposing HLA-DQ haplotypes in patients were HLA-DQ2.5 (46.7%) and HLA-DQ2.2 (11.6%), while the most prevalent genotypes were HLA-DQ2.5/DQX (58.3%) and HLA-DQ2.5/DQ2.2 (20.0%). The frequency of the HLA-DQ8 heterodimer among CD patients (4.2%) compared to the control group (8.1%) was without statistical significance. The given data demonstrate differences in the distribution of HLA haplotypes among Albanian CD patients from Kosovo in comparison to other European and non-European populations, as well as provide additional population data to supplement the thus far undisputed importance of the role of HLA-DQ2 and HLA-DQ8 heterodimers in the development of CD. |
| format | Article |
| id | doaj-art-27b7af2dfadb47ea94824a991feff9af |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-27b7af2dfadb47ea94824a991feff9af2025-08-20T03:54:41ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/73690147369014HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from KosovoAtifete Ramosaj-Morina0Marija Burek Kamenaric1Mehmedali Azemi2Lidvana Spahiu3Zorana Grubic4Renata Zunec5Pediatric Clinic, University Clinical Centre of Kosovo, Rrethi i Spitalit p.n., 10000 Prishtina, KosovoTissue Typing Centre, Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Kispaticeva 12, HR-10000 Zagreb, CroatiaPediatric Clinic, University Clinical Centre of Kosovo, Rrethi i Spitalit p.n., 10000 Prishtina, KosovoPediatric Clinic, University Clinical Centre of Kosovo, Rrethi i Spitalit p.n., 10000 Prishtina, KosovoTissue Typing Centre, Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Kispaticeva 12, HR-10000 Zagreb, CroatiaTissue Typing Centre, Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Kispaticeva 12, HR-10000 Zagreb, CroatiaGenetic predisposition to celiac disease (CD) is strongly associated with the presence of HLA alleles in the individual genotype encoding HLA-DQ2 and/or HLA-DQ8 heterodimers. The main aim of this study was to analyze the HLA-A, -B, -DRB1, and -DQ allele and five-locus haplotype frequencies in 60 Albanian pediatric CD patients and 124 non-CD children from Kosovo. The most prevalent haplotype in patients was the ancestral AH 8.1 haplotype present in 22.5% of the cases compared to 2.8% of the controls (P<0.0001). Additionally, two other haplotypes were also overrepresented in patients (HLA-A∗02~B∗50~DRB1∗07~DQA1∗02:01~DQB1∗02:02 and HLA-A∗68~B∗44~DRB1∗07~DQA1∗02:01~DQB1∗02:02). Analysis showed that 95.0% of CD patients and 43.3% of controls were carriers of HLA-DQ2 and/or HLA-DQ8 heterodimers. The most frequent CD-predisposing HLA-DQ haplotypes in patients were HLA-DQ2.5 (46.7%) and HLA-DQ2.2 (11.6%), while the most prevalent genotypes were HLA-DQ2.5/DQX (58.3%) and HLA-DQ2.5/DQ2.2 (20.0%). The frequency of the HLA-DQ8 heterodimer among CD patients (4.2%) compared to the control group (8.1%) was without statistical significance. The given data demonstrate differences in the distribution of HLA haplotypes among Albanian CD patients from Kosovo in comparison to other European and non-European populations, as well as provide additional population data to supplement the thus far undisputed importance of the role of HLA-DQ2 and HLA-DQ8 heterodimers in the development of CD.http://dx.doi.org/10.1155/2019/7369014 |
| spellingShingle | Atifete Ramosaj-Morina Marija Burek Kamenaric Mehmedali Azemi Lidvana Spahiu Zorana Grubic Renata Zunec HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo Gastroenterology Research and Practice |
| title | HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo |
| title_full | HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo |
| title_fullStr | HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo |
| title_full_unstemmed | HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo |
| title_short | HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo |
| title_sort | hla haplotype association with celiac disease in albanian pediatric patients from kosovo |
| url | http://dx.doi.org/10.1155/2019/7369014 |
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