Clinical Pharmacokinetics and Safety of a New HIV-1 Capsid Inhibitor, VH4004280, After Oral Administration in Adults Without HIV

Clinical Pharmacokinetics and Safety of a New HIV-1 Capsid Inhibitor, VH4004280, After Oral Administration in Adults Without HIV

Abstract Introduction The pharmacokinetics, drug–drug interaction potential, and safety of a new HIV-1 capsid inhibitor, VH4004280 (VH-280), are described in this first-time-in-human study. Methods This randomized, double-blind, placebo-controlled, phase 1 study assessed oral VH-280 in adults withou...

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Bibliographic Details
Main Authors: Nilay Thakkar, Rulan Griesel, Amy Pierce, Veronica Bainbridge, Bronagh Shepherd, Konstantinos Angelis, Andrew Tomlinson, Yash Gandhi, Darin Brimhall, Daijha Anderson, Susan Andrews, Carolina Acuipil, Cynthia McCoig, Mark Baker, Paul Benn
Format: Article
Language:English
Published: Adis, Springer Healthcare 2025-04-01
Series:Infectious Diseases and Therapy
Subjects:
Capsid inhibitor
Drug–drug interaction
First-time-in-human
HIV-1
Pharmacokinetics
Phase 1
Online Access:https://doi.org/10.1007/s40121-025-01154-x
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