Exploring the role of metabolic pathways in TNBC immunotherapy: insights from single-cell and spatial transcriptomics
The article provides an overview of the current understanding of the interplay between metabolic pathways and immune function in the context of triple-negative breast cancer (TNBC). It highlights recent advancements in single-cell and spatial transcriptomics technologies, which have revolutionized t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1528248/full |
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| author | Shi-liang Chen Yi-Ran Fei Yi-Ran Fei Xin-xian Cai Xin-xian Cai Cong Wang Shi-yuan Tong Zhe-zhong Zhang Yan-xia Huang Dan-dan Bian Yi-bo He Xiao-xiao Yang |
| author_facet | Shi-liang Chen Yi-Ran Fei Yi-Ran Fei Xin-xian Cai Xin-xian Cai Cong Wang Shi-yuan Tong Zhe-zhong Zhang Yan-xia Huang Dan-dan Bian Yi-bo He Xiao-xiao Yang |
| author_sort | Shi-liang Chen |
| collection | DOAJ |
| description | The article provides an overview of the current understanding of the interplay between metabolic pathways and immune function in the context of triple-negative breast cancer (TNBC). It highlights recent advancements in single-cell and spatial transcriptomics technologies, which have revolutionized the analysis of tumor heterogeneity and the immune microenvironment in TNBC. The review emphasizes the crucial role of metabolic reprogramming in modulating immune cell function, discussing how specific metabolic pathways, such as glycolysis, lipid metabolism, and amino acid metabolism, can directly impact the activity and phenotypes of various immune cell populations within the TNBC tumor microenvironment. Furthermore, the article explores the implications of these metabolic-immune interactions for the efficacy of immune checkpoint inhibitor (ICI) therapies in TNBC, suggesting that strategies targeting metabolic pathways may enhance the responsiveness to ICI treatments. Finally, the review outlines future directions and the potential for combination therapies that integrate metabolic modulation with immunotherapeutic approaches, offering promising avenues for improving clinical outcomes for TNBC patients. |
| format | Article |
| id | doaj-art-278921a91fe3454bb48d3699de91fed8 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-278921a91fe3454bb48d3699de91fed82025-01-09T05:10:20ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.15282481528248Exploring the role of metabolic pathways in TNBC immunotherapy: insights from single-cell and spatial transcriptomicsShi-liang Chen0Yi-Ran Fei1Yi-Ran Fei2Xin-xian Cai3Xin-xian Cai4Cong Wang5Shi-yuan Tong6Zhe-zhong Zhang7Yan-xia Huang8Dan-dan Bian9Yi-bo He10Xiao-xiao Yang11The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, ChinaThe First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, ChinaSchool of Medical Technology and Informmation Engineering, Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, ChinaState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, ChinaThe article provides an overview of the current understanding of the interplay between metabolic pathways and immune function in the context of triple-negative breast cancer (TNBC). It highlights recent advancements in single-cell and spatial transcriptomics technologies, which have revolutionized the analysis of tumor heterogeneity and the immune microenvironment in TNBC. The review emphasizes the crucial role of metabolic reprogramming in modulating immune cell function, discussing how specific metabolic pathways, such as glycolysis, lipid metabolism, and amino acid metabolism, can directly impact the activity and phenotypes of various immune cell populations within the TNBC tumor microenvironment. Furthermore, the article explores the implications of these metabolic-immune interactions for the efficacy of immune checkpoint inhibitor (ICI) therapies in TNBC, suggesting that strategies targeting metabolic pathways may enhance the responsiveness to ICI treatments. Finally, the review outlines future directions and the potential for combination therapies that integrate metabolic modulation with immunotherapeutic approaches, offering promising avenues for improving clinical outcomes for TNBC patients.https://www.frontiersin.org/articles/10.3389/fendo.2024.1528248/fulltriple-negative breast cancermetabolic reprogrammingimmune cell functionimmune checkpoint inhibitorscombination therapiestumor microenvironment |
| spellingShingle | Shi-liang Chen Yi-Ran Fei Yi-Ran Fei Xin-xian Cai Xin-xian Cai Cong Wang Shi-yuan Tong Zhe-zhong Zhang Yan-xia Huang Dan-dan Bian Yi-bo He Xiao-xiao Yang Exploring the role of metabolic pathways in TNBC immunotherapy: insights from single-cell and spatial transcriptomics Frontiers in Endocrinology triple-negative breast cancer metabolic reprogramming immune cell function immune checkpoint inhibitors combination therapies tumor microenvironment |
| title | Exploring the role of metabolic pathways in TNBC immunotherapy: insights from single-cell and spatial transcriptomics |
| title_full | Exploring the role of metabolic pathways in TNBC immunotherapy: insights from single-cell and spatial transcriptomics |
| title_fullStr | Exploring the role of metabolic pathways in TNBC immunotherapy: insights from single-cell and spatial transcriptomics |
| title_full_unstemmed | Exploring the role of metabolic pathways in TNBC immunotherapy: insights from single-cell and spatial transcriptomics |
| title_short | Exploring the role of metabolic pathways in TNBC immunotherapy: insights from single-cell and spatial transcriptomics |
| title_sort | exploring the role of metabolic pathways in tnbc immunotherapy insights from single cell and spatial transcriptomics |
| topic | triple-negative breast cancer metabolic reprogramming immune cell function immune checkpoint inhibitors combination therapies tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1528248/full |
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