Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study

Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study

Abstract Introduction The contribution of genetic and environmental factors to the relation between cerebrospinal fluid (CSF) biomarkers and cognitive decline in preclinical Alzheimer's disease remains unclear. We studied this in initially cognitively normal monozygotic twins. Methods We includ...

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Main Authors: Jori Tomassen, Anouk den Braber, Sophie M. van der Landen, Elles Konijnenberg, Charlotte E. Teunissen, Lisa Vermunt, Eco J. C. de Geus, Dorret I. Boomsma, Philip Scheltens, Betty M. Tijms, Pieter Jelle Visser
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
amyloid‐beta
biomarkers
cerebrospinal fluid
cognition
cognitive decline
longitudinal design
Online Access:https://doi.org/10.1002/trc2.12346
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