Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study
Abstract Introduction The contribution of genetic and environmental factors to the relation between cerebrospinal fluid (CSF) biomarkers and cognitive decline in preclinical Alzheimer's disease remains unclear. We studied this in initially cognitively normal monozygotic twins. Methods We includ...
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Wiley
2022-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
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| Online Access: | https://doi.org/10.1002/trc2.12346 |
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| author | Jori Tomassen Anouk den Braber Sophie M. van der Landen Elles Konijnenberg Charlotte E. Teunissen Lisa Vermunt Eco J. C. de Geus Dorret I. Boomsma Philip Scheltens Betty M. Tijms Pieter Jelle Visser |
| author_facet | Jori Tomassen Anouk den Braber Sophie M. van der Landen Elles Konijnenberg Charlotte E. Teunissen Lisa Vermunt Eco J. C. de Geus Dorret I. Boomsma Philip Scheltens Betty M. Tijms Pieter Jelle Visser |
| author_sort | Jori Tomassen |
| collection | DOAJ |
| description | Abstract Introduction The contribution of genetic and environmental factors to the relation between cerebrospinal fluid (CSF) biomarkers and cognitive decline in preclinical Alzheimer's disease remains unclear. We studied this in initially cognitively normal monozygotic twins. Methods We included 122 cognitively normal monozygotic twins (51 pairs) with a follow‐up of 4.3 ± 0.4 years. We first tested associations of baseline CSF Aβ1‐42/1‐40 ratio, total tau (t‐tau), and 181‐phosphorylated‐tau (p‐tau) status with subsequent cognitive decline using linear mixed models, and then performed twin specific analyses. Results Baseline abnormal amyloid‐β and tau CSF markers predicted steeper decline on memory (p ≤ .003) and language (p ≤ 0.04). Amyloid‐β and p‐tau markers in one twin predicted decline in memory in the co‐twin and tau markers in one twin predicted decline in language in the co‐twin (r range ‐0.26,0.39; p’s ≤ .02). Discussion These results suggest that memory and language decline are early features of AD that are in part determined by the same genetic factors that influence amyloid‐β and tau regulation. |
| format | Article |
| id | doaj-art-277af6272e3a491a827c46fdb6ccb8f0 |
| institution | Kabale University |
| issn | 2352-8737 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-277af6272e3a491a827c46fdb6ccb8f02024-12-03T12:37:31ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372022-01-0181n/an/a10.1002/trc2.12346Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin studyJori Tomassen0Anouk den Braber1Sophie M. van der Landen2Elles Konijnenberg3Charlotte E. Teunissen4Lisa Vermunt5Eco J. C. de Geus6Dorret I. Boomsma7Philip Scheltens8Betty M. Tijms9Pieter Jelle Visser10Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam The NetherlandsAlzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam The NetherlandsAlzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam The NetherlandsAlzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam The NetherlandsAmsterdam Neuroscience Neurodegeneration Amsterdam The NetherlandsAlzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam The NetherlandsDepartment of Biological Psychology Vrije Universiteit Amsterdam Amsterdam The NetherlandsDepartment of Biological Psychology Vrije Universiteit Amsterdam Amsterdam The NetherlandsAlzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam The NetherlandsAlzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam The NetherlandsAlzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam The NetherlandsAbstract Introduction The contribution of genetic and environmental factors to the relation between cerebrospinal fluid (CSF) biomarkers and cognitive decline in preclinical Alzheimer's disease remains unclear. We studied this in initially cognitively normal monozygotic twins. Methods We included 122 cognitively normal monozygotic twins (51 pairs) with a follow‐up of 4.3 ± 0.4 years. We first tested associations of baseline CSF Aβ1‐42/1‐40 ratio, total tau (t‐tau), and 181‐phosphorylated‐tau (p‐tau) status with subsequent cognitive decline using linear mixed models, and then performed twin specific analyses. Results Baseline abnormal amyloid‐β and tau CSF markers predicted steeper decline on memory (p ≤ .003) and language (p ≤ 0.04). Amyloid‐β and p‐tau markers in one twin predicted decline in memory in the co‐twin and tau markers in one twin predicted decline in language in the co‐twin (r range ‐0.26,0.39; p’s ≤ .02). Discussion These results suggest that memory and language decline are early features of AD that are in part determined by the same genetic factors that influence amyloid‐β and tau regulation.https://doi.org/10.1002/trc2.12346amyloid‐betabiomarkerscerebrospinal fluidcognitioncognitive declinelongitudinal design |
| spellingShingle | Jori Tomassen Anouk den Braber Sophie M. van der Landen Elles Konijnenberg Charlotte E. Teunissen Lisa Vermunt Eco J. C. de Geus Dorret I. Boomsma Philip Scheltens Betty M. Tijms Pieter Jelle Visser Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study Alzheimer’s & Dementia: Translational Research & Clinical Interventions amyloid‐beta biomarkers cerebrospinal fluid cognition cognitive decline longitudinal design |
| title | Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study |
| title_full | Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study |
| title_fullStr | Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study |
| title_full_unstemmed | Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study |
| title_short | Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study |
| title_sort | abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults a monozygotic twin study |
| topic | amyloid‐beta biomarkers cerebrospinal fluid cognition cognitive decline longitudinal design |
| url | https://doi.org/10.1002/trc2.12346 |
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