Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction

Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction

Abstract Senescent hepatocytes accumulate in metabolic dysfunction-associated steatotic liver disease (MASLD) and are linked to worse clinical outcomes. However, their heterogeneity and lack of specific markers have made them difficult to target therapeutically. Here, we define a senescent hepatocyt...

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Main Authors: Kuo Du, David S. Umbaugh, Liuyang Wang, Ji Hye Jun, Rajesh K. Dutta, Seh Hoon Oh, Niansheng Ren, Qiaojuan Zhang, Dennis C. Ko, Ana Ferreira, Jon Hill, Guannan Gao, Steven S. Pullen, Vaibhav Jain, Simon Gregory, Manal F. Abdelmalek, Anna Mae Diehl
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57616-w
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