Developing a translational research framework for MDD: combining biomolecular mechanisms with a spiraling risk factor model

Developing a translational research framework for MDD: combining biomolecular mechanisms with a spiraling risk factor model

ObjectiveThe global incidence and burden of Major Depressive Disorder (MDD) are increasing annually, with current antidepressant treatments proving ineffective for 30-40% of patients. Biomolecular mechanisms within the microbiota-gut-brain axis (MGBA) may significantly contribute to MDD, potentially...

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Bibliographic Details
Main Authors: Max van Baalen, Lars van der Velden, Toon van der Gronde, Toine Pieters
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Psychiatry
Subjects:
MDD (major depressive disorder)
microbiota-gut-brain axis
HPA axis
pro-inflammatory state
translational research framework
dysbiosis
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1463929/full
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