Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants
BackgroundAntibiotics, as the most commonly prescribed class of drugs in neonatal intensive care units, have an important impact on the developing neonatal gut microbiota. Therefore, comprehending the effects of commonly used antibiotic therapy on the gut microbiota and butyrate-producers in early i...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1508217/full |
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| author | Jun Qiu Jun Qiu Sha Wu Sha Wu Ruiwen Huang Zhenyu Liao Xiongfeng Pan Kunyan Zhao Kunyan Zhao Yunlong Peng Yunlong Peng Shiting Xiang Yunhui Cao Yunhui Cao Ye Ma Zhenghui Xiao Zhenghui Xiao |
| author_facet | Jun Qiu Jun Qiu Sha Wu Sha Wu Ruiwen Huang Zhenyu Liao Xiongfeng Pan Kunyan Zhao Kunyan Zhao Yunlong Peng Yunlong Peng Shiting Xiang Yunhui Cao Yunhui Cao Ye Ma Zhenghui Xiao Zhenghui Xiao |
| author_sort | Jun Qiu |
| collection | DOAJ |
| description | BackgroundAntibiotics, as the most commonly prescribed class of drugs in neonatal intensive care units, have an important impact on the developing neonatal gut microbiota. Therefore, comprehending the effects of commonly used antibiotic therapy on the gut microbiota and butyrate-producers in early infants could provide information for therapeutic decision-making in the NICU.ObjectivesTo explore the effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants.MethodsA total of 72 infants were included in the study. We performed 16S rRNA sequencing on stool swab samples collected from neonatal intensive care unit patients who received amoxicillin-clavulanic acid (AC, n = 10), moxalactam (ML, n = 28) and non-antibiotics (NA, n = 34). We then compared the taxonomic composition between treatment regimens, focusing on differences in butyrate-producers.ResultsOur study showed that there were significant differences in Shannon index (p = 0.033) and Beta diversity (p = 0.014) among the three groups. At the family level, compared with the other two groups, the relative abundance of Clostridiaceae (p < 0.001) and Veillonellaceae (p = 0.004) were significantly higher, while the relative abundance of Enterococcidae (p < 0.001) was significantly lower in the NA group. The relative abundance of Enterobacteriaceae (p = 0.022) in the AC group was greater than that in the other two groups. Additionally, butyrate-producers (p < 0.001), especially Clostridiaceae (p < 0.001), were noticeably more abundant in the NA group. The relative abundance of Clostridiaceae and butyrate-producers were the lowest in the ML group (p < 0.001).ConclusionWe found that antibiotic therapy had an adverse impact on the initial development of gut microbiota and leaded to a reduction in the abundance of butyrate-producers, particularly Clostridiaceae. Furthermore, moxalactam had a more pronounced effect on the gut microbiota compared to amoxicillin-clavulanic acid. |
| format | Article |
| id | doaj-art-27371e663fd943279876a8f943ce298b |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Microbiology |
| spelling | doaj-art-27371e663fd943279876a8f943ce298b2025-01-07T15:03:07ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011510.3389/fmicb.2024.15082171508217Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infantsJun Qiu0Jun Qiu1Sha Wu2Sha Wu3Ruiwen Huang4Zhenyu Liao5Xiongfeng Pan6Kunyan Zhao7Kunyan Zhao8Yunlong Peng9Yunlong Peng10Shiting Xiang11Yunhui Cao12Yunhui Cao13Ye Ma14Zhenghui Xiao15Zhenghui Xiao16The School of Pediatrics, Hengyang Medical School, University of South China, Hunan Children’s Hospital, Hengyang, Hunan, ChinaPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, Hunan, ChinaThe School of Pediatrics, Hengyang Medical School, University of South China, Hunan Children’s Hospital, Hengyang, Hunan, ChinaPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Children's Hospital, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Children's Hospital, Changsha, Hunan, ChinaPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, Hunan, ChinaPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, Hunan, ChinaThe School of Public Health, University of South China, Hengyang, ChinaPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, Hunan, ChinaDepartment of Epidemiology and Health Statistics, Medical College of Soochow University, Suzhou, ChinaPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, Hunan, ChinaThe School of Pediatrics, Hengyang Medical School, University of South China, Hunan Children’s Hospital, Hengyang, Hunan, ChinaPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, Hunan, ChinaDepartment of Neonatology, Hunan Children's Hospital, Changsha, Hunan, ChinaThe School of Pediatrics, Hengyang Medical School, University of South China, Hunan Children’s Hospital, Hengyang, Hunan, ChinaDepartment of Emergency Center, Hunan Children’s Hospital, Changsha, ChinaBackgroundAntibiotics, as the most commonly prescribed class of drugs in neonatal intensive care units, have an important impact on the developing neonatal gut microbiota. Therefore, comprehending the effects of commonly used antibiotic therapy on the gut microbiota and butyrate-producers in early infants could provide information for therapeutic decision-making in the NICU.ObjectivesTo explore the effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants.MethodsA total of 72 infants were included in the study. We performed 16S rRNA sequencing on stool swab samples collected from neonatal intensive care unit patients who received amoxicillin-clavulanic acid (AC, n = 10), moxalactam (ML, n = 28) and non-antibiotics (NA, n = 34). We then compared the taxonomic composition between treatment regimens, focusing on differences in butyrate-producers.ResultsOur study showed that there were significant differences in Shannon index (p = 0.033) and Beta diversity (p = 0.014) among the three groups. At the family level, compared with the other two groups, the relative abundance of Clostridiaceae (p < 0.001) and Veillonellaceae (p = 0.004) were significantly higher, while the relative abundance of Enterococcidae (p < 0.001) was significantly lower in the NA group. The relative abundance of Enterobacteriaceae (p = 0.022) in the AC group was greater than that in the other two groups. Additionally, butyrate-producers (p < 0.001), especially Clostridiaceae (p < 0.001), were noticeably more abundant in the NA group. The relative abundance of Clostridiaceae and butyrate-producers were the lowest in the ML group (p < 0.001).ConclusionWe found that antibiotic therapy had an adverse impact on the initial development of gut microbiota and leaded to a reduction in the abundance of butyrate-producers, particularly Clostridiaceae. Furthermore, moxalactam had a more pronounced effect on the gut microbiota compared to amoxicillin-clavulanic acid.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1508217/fullgut microbiotaantibioticsamoxicillin-clavulanic acidmoxalactambutyrate-producers |
| spellingShingle | Jun Qiu Jun Qiu Sha Wu Sha Wu Ruiwen Huang Zhenyu Liao Xiongfeng Pan Kunyan Zhao Kunyan Zhao Yunlong Peng Yunlong Peng Shiting Xiang Yunhui Cao Yunhui Cao Ye Ma Zhenghui Xiao Zhenghui Xiao Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants Frontiers in Microbiology gut microbiota antibiotics amoxicillin-clavulanic acid moxalactam butyrate-producers |
| title | Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants |
| title_full | Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants |
| title_fullStr | Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants |
| title_full_unstemmed | Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants |
| title_short | Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants |
| title_sort | effects of antibiotic therapy on the early development of gut microbiota and butyrate producers in early infants |
| topic | gut microbiota antibiotics amoxicillin-clavulanic acid moxalactam butyrate-producers |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1508217/full |
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