Lack of glutamate neurotransmission in melanin-concentrating hormone neurons alters mouse reproduction and metabolism in a sex-specific manner

Lack of glutamate neurotransmission in melanin-concentrating hormone neurons alters mouse reproduction and metabolism in a sex-specific manner

Plain language summary Melanin-concentrating hormone (MCH) is a neuropeptide important for the regulation of metabolism, sleep, circadian rhythms, and other body functions. MCH neurons contain the excitatory neurotransmitter glutamate, which is released via vesicular glutamate transporter 2 (VGLUT2)...

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Bibliographic Details
Main Authors: Bethany G. Beekly, Dania Zeidan, Wenicios F. Chaves, Jonah-Isabella Sta-Monica, Thomas Saunders, Cristina Saenz de Miera, Christian R. Burgess, Carol F. Elias
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Biology of Sex Differences
Subjects:
Lateral hypothalamus
Puberty
Metabolism
Reproduction
Energy homeostasis
Glucose tolerance
Online Access:https://doi.org/10.1186/s13293-025-00742-3
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