PDZ domains of PATJ facilitate immunological synapse formation to promote T cell activation

PDZ domains of PATJ facilitate immunological synapse formation to promote T cell activation

Background The highly organized structures of the immunological synapse (IS) are crucial for T cell activation. PDZ domains might be involved in the formation of the IS by serving as docking sites for protein interactions. In this study, we investigate the role of the PALS1-associated tight junction...

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Main Authors: Xiaomin Zhang, Siyu Chen, Penghui Zhou, Danyang Wang, Liping Xu, Jingjing He, Wende Li, Xinxin Xiong, Ziqian Fang, Jianeng Zhang
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/5/e010966.full
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