TRIF-TAK1 signaling suppresses caspase-8/3-mediated GSDMD/E activation and pyroptosis in influenza A virus-infected airway epithelial cells

TRIF-TAK1 signaling suppresses caspase-8/3-mediated GSDMD/E activation and pyroptosis in influenza A virus-infected airway epithelial cells

Summary: Pyroptosis plays an important role in attracting innate immune cells to eliminate infected niches. Our study focuses on how influenza A virus (IAV) infection triggers pyroptosis in respiratory epithelial cells. Here, we report that IAV infection induces pyroptosis in a human and murine airw...

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Bibliographic Details
Main Authors: Yuling Sun, Huidi Yu, Zhihao Zhan, Wei Liu, Penggang Liu, Jing Sun, Pinghu Zhang, Xiaoquan Wang, Xiufan Liu, Xiulong Xu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:iScience
Subjects:
molecular network
virology
cell biology
integrative aspects of cell biology
model organism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224028086
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