Association of platelet-to-lymphocyte ratio with 1-year all-cause mortality in ICU patients with heart failure
Abstract The Platelet-to-Lymphocyte Ratio (PLR) has emerged as a cost-effective biomarker for systemic inflammation and adverse cardiovascular outcomes, yet its prognostic value in critically ill patients with heart failure (HF) remains unclear. Leveraging the MIMIC-IV database, this study investiga...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83583-1 |
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| author | Xinyu Hu Shijiao Cheng Huaan Du Yuehui Yin |
| author_facet | Xinyu Hu Shijiao Cheng Huaan Du Yuehui Yin |
| author_sort | Xinyu Hu |
| collection | DOAJ |
| description | Abstract The Platelet-to-Lymphocyte Ratio (PLR) has emerged as a cost-effective biomarker for systemic inflammation and adverse cardiovascular outcomes, yet its prognostic value in critically ill patients with heart failure (HF) remains unclear. Leveraging the MIMIC-IV database, this study investigates the association between PLR and 1-year all-cause mortality in 7,217 ICU patients with HF. Patients were stratified into tertiles (0–126.45, 126.45–252.40, and 252.40–1000), and mortality risk was analyzed using Kaplan-Meier survival curves and Cox proportional hazards models. Elevated PLR was independently associated with higher mortality, with the highest tertile showing a 36% increased risk compared to the lowest (HR 1.36, 95% CI: 1.23–1.50, P < 0.001). Each tertile increment corresponded to a 17% rise in risk. Subgroup analyses revealed stronger associations in hypertensive patients and identified renal dysfunction and red cell distribution width as key modifiers. Integrating PLR with SOFA and APS III scores significantly enhanced predictive accuracy. By reflecting systemic inflammation and immune dysregulation, PLR offers a robust tool for long-term risk stratification and personalized management of ICU patients with HF. These findings highlight the potential of PLR to refine prognostic models, guide clinical decision-making, and improve critical care outcomes. |
| format | Article |
| id | doaj-art-26c417787d4848edb63f1a7ba8e9836a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-26c417787d4848edb63f1a7ba8e9836a2025-01-05T12:27:48ZengNature PortfolioScientific Reports2045-23222024-12-011411910.1038/s41598-024-83583-1Association of platelet-to-lymphocyte ratio with 1-year all-cause mortality in ICU patients with heart failureXinyu Hu0Shijiao Cheng1Huaan Du2Yuehui Yin3Department of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Medical Affairs, Chongqing University Fuling HospitalDepartment of Cardiovascular Medicine, University-Town Hospital of Chongqing Medical UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical UniversityAbstract The Platelet-to-Lymphocyte Ratio (PLR) has emerged as a cost-effective biomarker for systemic inflammation and adverse cardiovascular outcomes, yet its prognostic value in critically ill patients with heart failure (HF) remains unclear. Leveraging the MIMIC-IV database, this study investigates the association between PLR and 1-year all-cause mortality in 7,217 ICU patients with HF. Patients were stratified into tertiles (0–126.45, 126.45–252.40, and 252.40–1000), and mortality risk was analyzed using Kaplan-Meier survival curves and Cox proportional hazards models. Elevated PLR was independently associated with higher mortality, with the highest tertile showing a 36% increased risk compared to the lowest (HR 1.36, 95% CI: 1.23–1.50, P < 0.001). Each tertile increment corresponded to a 17% rise in risk. Subgroup analyses revealed stronger associations in hypertensive patients and identified renal dysfunction and red cell distribution width as key modifiers. Integrating PLR with SOFA and APS III scores significantly enhanced predictive accuracy. By reflecting systemic inflammation and immune dysregulation, PLR offers a robust tool for long-term risk stratification and personalized management of ICU patients with HF. These findings highlight the potential of PLR to refine prognostic models, guide clinical decision-making, and improve critical care outcomes.https://doi.org/10.1038/s41598-024-83583-1PLRHeart failureAll-cause mortalityInflammationMIMIC-IV |
| spellingShingle | Xinyu Hu Shijiao Cheng Huaan Du Yuehui Yin Association of platelet-to-lymphocyte ratio with 1-year all-cause mortality in ICU patients with heart failure Scientific Reports PLR Heart failure All-cause mortality Inflammation MIMIC-IV |
| title | Association of platelet-to-lymphocyte ratio with 1-year all-cause mortality in ICU patients with heart failure |
| title_full | Association of platelet-to-lymphocyte ratio with 1-year all-cause mortality in ICU patients with heart failure |
| title_fullStr | Association of platelet-to-lymphocyte ratio with 1-year all-cause mortality in ICU patients with heart failure |
| title_full_unstemmed | Association of platelet-to-lymphocyte ratio with 1-year all-cause mortality in ICU patients with heart failure |
| title_short | Association of platelet-to-lymphocyte ratio with 1-year all-cause mortality in ICU patients with heart failure |
| title_sort | association of platelet to lymphocyte ratio with 1 year all cause mortality in icu patients with heart failure |
| topic | PLR Heart failure All-cause mortality Inflammation MIMIC-IV |
| url | https://doi.org/10.1038/s41598-024-83583-1 |
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