Prrx1-driven LINC complex disruption in vivo reduces osteoid deposition but not bone quality after voluntary wheel running.

Prrx1-driven LINC complex disruption in vivo reduces osteoid deposition but not bone quality after voluntary wheel running.

The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex serves to connect the nuclear envelope and the cytoskeleton, influencing cellular processes such as nuclear arrangement, architecture, and mechanotransduction. The role LINC plays in mechanotransduction pathways in bone progenitor cells ha...

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Main Authors: Scott Birks, Sean Howard, Christian S Wright, Caroline O'Rourke, Elicza A Day, Alexander J Lamb, James R Walsdorf, Anthony Lau, William R Thompson, Gunes Uzer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0307816
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https://doi.org/10.1371/journal.pone.0307816

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