Prenatal Hyperhomocysteinemia Leads to Synaptic Dysfunction and Structural Alterations in the CA1 Hippocampus of Rats

Prenatal Hyperhomocysteinemia Leads to Synaptic Dysfunction and Structural Alterations in the CA1 Hippocampus of Rats

Prenatal hyperhomocysteinemia (HCY) is associated with neurodevelopmental deficits, yet its long-term impact on hippocampal synaptic function remains poorly understood. This study examines the effects of moderate maternal HCY on excitatory synaptic transmission in the CA1 region of the dorsal hippoc...

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Bibliographic Details
Main Authors: Tatyana Y. Postnikova, Alexandra V. Griflyuk, Natalia L. Tumanova, Nadezhda M. Dubrovskaya, Anastasia V. Mikhel, Dmitriy S. Vasilev, Aleksey V. Zaitsev
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Biomolecules
Subjects:
homocysteine
maximal electroshock threshold test
hippocampus
CA1
synaptic vesicles
field postsynaptic potentials
Online Access:https://www.mdpi.com/2218-273X/15/2/305
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