Formation of the Native Topology of a Protein is due to the “Conserved but Non-Functional” Residues: A Case of Apomyoglobin Folding

Formation of the Native Topology of a Protein is due to the “Conserved but Non-Functional” Residues: A Case of Apomyoglobin Folding

This paper is dedicated to the memory of Oleg B. Ptitsyn (1929-1999) and presents an answer to his question: “What is the role of conserved non-functional residues in protein folding?”. This answer follows from the experimental works of three labs. The role of non-functional but conserved residues o...

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Bibliographic Details
Main Authors: Valentina E. Bychkova, Dmitry A. Dolgikh, Vitalii A. Balobanov, Alexei V. Finkelstein
Format: Article
Language:English
Published: IMR Press 2024-11-01
Series:Frontiers in Bioscience-Landmark
Subjects:
globin
apomyoglobin
conserved residues
non-functional residues
protein stability
protein folding
folding intermediate
native fold topology
Online Access:https://www.imrpress.com/journal/FBL/29/11/10.31083/j.fbl2911379
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