A novel integrated nutrition-combined prognostic index for predicting overall survival after radical gastrectomy
ObjectiveThe objectives of this study were to integrate the Prognostic Nutritional Index, Controlling Nutritional Status, and Nutritional Risk Index, into a novel Nutrition-combined Prognostic Index (NCPI), and to develop and validate a nomogram to predict overall survival (OS) in patients with gast...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1438319/full |
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| author | Xiang Li Xiang Li Zhongxue Fu Jun Zhang Jinming Xu Lianwei Wang Ke Li |
| author_facet | Xiang Li Xiang Li Zhongxue Fu Jun Zhang Jinming Xu Lianwei Wang Ke Li |
| author_sort | Xiang Li |
| collection | DOAJ |
| description | ObjectiveThe objectives of this study were to integrate the Prognostic Nutritional Index, Controlling Nutritional Status, and Nutritional Risk Index, into a novel Nutrition-combined Prognostic Index (NCPI), and to develop and validate a nomogram to predict overall survival (OS) in patients with gastric cancer (GC).Materials and methodsData from 609 patients with GC, collected between January 1, 2017, and April 30, 2023, were retrospectively analyzed. Optimal cut-off values for nutritional parameters were determined using X-Tile software, and the Kaplan–Meier method applied for survival analysis. Univariate, least absolute shrinkage and selection operator, and multivariate Cox regression analyses were conducted, and a nomogram for predicting OS in patients with GC constructed and validated.ResultsInferior nutritional status was strongly correlated with worse clinicopathologic features and prognosis of patients with GC. NCPI, body mass index, American Joint Committee on Cancer T stage, and lymph node ratio were identified as independent risk factors for OS. A nomogram including these factors predicted 1-, 3-, and 5-year OS, with training and validation set C-index values of 0.716 and 0.77, respectively. Calibration curves demonstrated that the predicted outcomes closely matched the actual results, and decision curve analysis highlighted the high practical value of the model.ConclusionThe novel nutritional marker, NCPI, is closely associated with the clinicopathologic features and OS of patients with GC. The practical value of the NCPI-based nomogram was demonstrated and a web-based calculator developed. |
| format | Article |
| id | doaj-art-2686a0ddcc844eaf8a9c2c34c52cfd46 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-2686a0ddcc844eaf8a9c2c34c52cfd462024-11-18T04:22:53ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-11-011110.3389/fnut.2024.14383191438319A novel integrated nutrition-combined prognostic index for predicting overall survival after radical gastrectomyXiang Li0Xiang Li1Zhongxue Fu2Jun Zhang3Jinming Xu4Lianwei Wang5Ke Li6Department of Gastrointestinal Surgery, Chongqing University FuLing Hospital, Chongqing, ChinaDepartment of General Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of General Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Gastrointestinal Surgery, Chongqing University FuLing Hospital, Chongqing, ChinaDepartment of Gastrointestinal Surgery, Chongqing University FuLing Hospital, Chongqing, ChinaDepartment of Gastrointestinal Surgery, Chongqing University FuLing Hospital, Chongqing, ChinaObjectiveThe objectives of this study were to integrate the Prognostic Nutritional Index, Controlling Nutritional Status, and Nutritional Risk Index, into a novel Nutrition-combined Prognostic Index (NCPI), and to develop and validate a nomogram to predict overall survival (OS) in patients with gastric cancer (GC).Materials and methodsData from 609 patients with GC, collected between January 1, 2017, and April 30, 2023, were retrospectively analyzed. Optimal cut-off values for nutritional parameters were determined using X-Tile software, and the Kaplan–Meier method applied for survival analysis. Univariate, least absolute shrinkage and selection operator, and multivariate Cox regression analyses were conducted, and a nomogram for predicting OS in patients with GC constructed and validated.ResultsInferior nutritional status was strongly correlated with worse clinicopathologic features and prognosis of patients with GC. NCPI, body mass index, American Joint Committee on Cancer T stage, and lymph node ratio were identified as independent risk factors for OS. A nomogram including these factors predicted 1-, 3-, and 5-year OS, with training and validation set C-index values of 0.716 and 0.77, respectively. Calibration curves demonstrated that the predicted outcomes closely matched the actual results, and decision curve analysis highlighted the high practical value of the model.ConclusionThe novel nutritional marker, NCPI, is closely associated with the clinicopathologic features and OS of patients with GC. The practical value of the NCPI-based nomogram was demonstrated and a web-based calculator developed.https://www.frontiersin.org/articles/10.3389/fnut.2024.1438319/fullgastric cancernutrition-combined prognostic indexnomogramoverall survivalnutrition |
| spellingShingle | Xiang Li Xiang Li Zhongxue Fu Jun Zhang Jinming Xu Lianwei Wang Ke Li A novel integrated nutrition-combined prognostic index for predicting overall survival after radical gastrectomy Frontiers in Nutrition gastric cancer nutrition-combined prognostic index nomogram overall survival nutrition |
| title | A novel integrated nutrition-combined prognostic index for predicting overall survival after radical gastrectomy |
| title_full | A novel integrated nutrition-combined prognostic index for predicting overall survival after radical gastrectomy |
| title_fullStr | A novel integrated nutrition-combined prognostic index for predicting overall survival after radical gastrectomy |
| title_full_unstemmed | A novel integrated nutrition-combined prognostic index for predicting overall survival after radical gastrectomy |
| title_short | A novel integrated nutrition-combined prognostic index for predicting overall survival after radical gastrectomy |
| title_sort | novel integrated nutrition combined prognostic index for predicting overall survival after radical gastrectomy |
| topic | gastric cancer nutrition-combined prognostic index nomogram overall survival nutrition |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1438319/full |
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