Research progress on the association between neutrophil extracellular traps and oral squamous cell carcinoma
Neutrophil extracellular traps (NETs) are fibrous web-like structures composed of decondensed chromatin and granular proteins released by neutrophils, with the ability to capture and kill bacteria. Pathogens, such as bacteria and viruses, can trigger the formation of NETs via NETosis, a type of prog...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2024-11-01
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| Series: | 口腔疾病防治 |
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| Online Access: | https://www.kqjbfz.com/fileup/2096-1456/PDF/2096-1456（2024）11-0894-07.pdf |
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| _version_ | 1846162815598985216 |
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| author | YANG Shengfeng, GU Xin, ZHANG Rui, SONG Hongquan |
| author_facet | YANG Shengfeng, GU Xin, ZHANG Rui, SONG Hongquan |
| author_sort | YANG Shengfeng, GU Xin, ZHANG Rui, SONG Hongquan |
| collection | DOAJ |
| description | Neutrophil extracellular traps (NETs) are fibrous web-like structures composed of decondensed chromatin and granular proteins released by neutrophils, with the ability to capture and kill bacteria. Pathogens, such as bacteria and viruses, can trigger the formation of NETs via NETosis, a type of programmed cell death that has two distinct forms: suicidal NETosis and vital NETosis. Numerous studies have found that NETs interact with immune cells in the tumor microenvironment, where they activate macrophages, promote immunosuppressive effects of myeloid-derived suppressor cells, and coat the tumor surface to prevent cytotoxic effects of CD8<sup>+</sup> T cells and natural killer cells. Recent research has identified a substantial presence of NETs in oral squamous cell carcinoma (OSCC) tissues, indicating a complex relationship between NETs and OSCC development. Depending on the phenotype of neutrophils, NETs may exhibit pro-tumor or anti-tumor effects. For instance, NETs derived from N1-type neutrophils may exert anti-tumor effects, while TGF-β-induced NETs derived from N2-type neutrophils may exert pro-carcinogenic activity, thereby contributing to the development of oral squamous metaplasia. Furthermore, NETs likely play a role in OSCC metastasis by capturing circulating tumor cells and inducing a hypercoagulable state, thereby facilitating tumor-related thrombus formation and hematogenous metastasis. The involvement of NETs in the occurrence and progression of OSCC opens new avenues for anti-tumor therapy and prognostication. Inhibiting NET formation can significantly suppress the development of chemotherapy-induced drug resistance and reduce the risk of thrombosis in OSCC patients, thereby inhibiting tumor metastasis. Currently, multiple prognostic models based on NET-related genes have been constructed and validated for head and neck squamous cell carcinoma, indicating the potential clinical value of NETs. However, the association between NETs and OSCC treatment is still unclear, necessitating further research on its underlying mechanisms and feasibility. This article attempts to review the relationship between NETs and OSCC, aiming to provide novel perspectives for OSCC treatment. |
| format | Article |
| id | doaj-art-2661ad5ee6e34b57beca1808b7fbf00f |
| institution | Kabale University |
| issn | 2096-1456 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj-art-2661ad5ee6e34b57beca1808b7fbf00f2024-11-20T03:19:22ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562024-11-01321189490010.12016/j.issn.2096-1456.202330441Research progress on the association between neutrophil extracellular traps and oral squamous cell carcinomaYANG Shengfeng, GU Xin, ZHANG Rui, SONG Hongquan01 School of Stomatology, Harbin Medical University, Harbin 150001, China;2 Department of Stomatology, Nangang Branch of Heilongjiang Province Hospital, Harbin 150001, China;3 Oral Maxillofacial Department, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, ChinaNeutrophil extracellular traps (NETs) are fibrous web-like structures composed of decondensed chromatin and granular proteins released by neutrophils, with the ability to capture and kill bacteria. Pathogens, such as bacteria and viruses, can trigger the formation of NETs via NETosis, a type of programmed cell death that has two distinct forms: suicidal NETosis and vital NETosis. Numerous studies have found that NETs interact with immune cells in the tumor microenvironment, where they activate macrophages, promote immunosuppressive effects of myeloid-derived suppressor cells, and coat the tumor surface to prevent cytotoxic effects of CD8<sup>+</sup> T cells and natural killer cells. Recent research has identified a substantial presence of NETs in oral squamous cell carcinoma (OSCC) tissues, indicating a complex relationship between NETs and OSCC development. Depending on the phenotype of neutrophils, NETs may exhibit pro-tumor or anti-tumor effects. For instance, NETs derived from N1-type neutrophils may exert anti-tumor effects, while TGF-β-induced NETs derived from N2-type neutrophils may exert pro-carcinogenic activity, thereby contributing to the development of oral squamous metaplasia. Furthermore, NETs likely play a role in OSCC metastasis by capturing circulating tumor cells and inducing a hypercoagulable state, thereby facilitating tumor-related thrombus formation and hematogenous metastasis. The involvement of NETs in the occurrence and progression of OSCC opens new avenues for anti-tumor therapy and prognostication. Inhibiting NET formation can significantly suppress the development of chemotherapy-induced drug resistance and reduce the risk of thrombosis in OSCC patients, thereby inhibiting tumor metastasis. Currently, multiple prognostic models based on NET-related genes have been constructed and validated for head and neck squamous cell carcinoma, indicating the potential clinical value of NETs. However, the association between NETs and OSCC treatment is still unclear, necessitating further research on its underlying mechanisms and feasibility. This article attempts to review the relationship between NETs and OSCC, aiming to provide novel perspectives for OSCC treatment.https://www.kqjbfz.com/fileup/2096-1456/PDF/2096-1456（2024）11-0894-07.pdfneutrophil|neutrophil extracellular traps|macrophage|cd8<sup>+</sup> t cells|natural killer cells|myeloid suppressor cells|oral squamous cell carcinoma|tumor metastasis|tumor microenvironment|circulating tumor cell|chemotherapy resistance|myeloperoxidase|circulating free dna |
| spellingShingle | YANG Shengfeng, GU Xin, ZHANG Rui, SONG Hongquan Research progress on the association between neutrophil extracellular traps and oral squamous cell carcinoma 口腔疾病防治 neutrophil|neutrophil extracellular traps|macrophage|cd8<sup>+</sup> t cells|natural killer cells|myeloid suppressor cells|oral squamous cell carcinoma|tumor metastasis|tumor microenvironment|circulating tumor cell|chemotherapy resistance|myeloperoxidase|circulating free dna |
| title | Research progress on the association between neutrophil extracellular traps and oral squamous cell carcinoma |
| title_full | Research progress on the association between neutrophil extracellular traps and oral squamous cell carcinoma |
| title_fullStr | Research progress on the association between neutrophil extracellular traps and oral squamous cell carcinoma |
| title_full_unstemmed | Research progress on the association between neutrophil extracellular traps and oral squamous cell carcinoma |
| title_short | Research progress on the association between neutrophil extracellular traps and oral squamous cell carcinoma |
| title_sort | research progress on the association between neutrophil extracellular traps and oral squamous cell carcinoma |
| topic | neutrophil|neutrophil extracellular traps|macrophage|cd8<sup>+</sup> t cells|natural killer cells|myeloid suppressor cells|oral squamous cell carcinoma|tumor metastasis|tumor microenvironment|circulating tumor cell|chemotherapy resistance|myeloperoxidase|circulating free dna |
| url | https://www.kqjbfz.com/fileup/2096-1456/PDF/2096-1456（2024）11-0894-07.pdf |
| work_keys_str_mv | AT yangshengfengguxinzhangruisonghongquan researchprogressontheassociationbetweenneutrophilextracellulartrapsandoralsquamouscellcarcinoma |