Combination Treatment of Resistant Acute Promyelocytic Leukemia Cells with Arsenic Trioxide and Anti-Apoptotic Gene Inhibitors

Combination Treatment of Resistant Acute Promyelocytic Leukemia Cells with Arsenic Trioxide and Anti-Apoptotic Gene Inhibitors

Background: Arsenic trioxide (ATO) is an anticancer agent for treating acute promyelocytic leukemia (APL). However, 5–10% of patients fail to respond, developing relapsed/refractory disease. The aim of this study was to identify potential new therapeutic approaches for ATO-unresponsive APL by target...

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Bibliographic Details
Main Authors: Manuela Giansanti, Tiziana Ottone, Serena Travaglini, Maria Teresa Voso, Grazia Graziani, Isabella Faraoni
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceuticals
Subjects:
APL
arsenic resistance
apoptosis
BCL2
venetoclax
BIRC3
Online Access:https://www.mdpi.com/1424-8247/17/11/1529
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