Single-nucleus transcriptomic profiling of the diaphragm during mechanical ventilation

Single-nucleus transcriptomic profiling of the diaphragm during mechanical ventilation

Abstract Mechanical ventilation contributes to diaphragm atrophy and muscle weakness, which is referred to as ventilator-induced diaphragmatic dysfunction (VIDD). The pathogenesis of VIDD has not been fully understood until recently. The aim of this study was to investigate the effects of 24 h of me...

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Bibliographic Details
Main Authors: Lei Li, Feng Jiang, Wenyan Hao, Yu Wang, Yaqian Li, Dong Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Single-nucleus RNA sequencing
Diaphragm fibrosis
Fibro-adipogenic progenitor
High dimensional weighted gene coexpression network analysis
Endothelial-mesenchymal transition
Online Access:https://doi.org/10.1038/s41598-024-82530-4
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https://doi.org/10.1038/s41598-024-82530-4

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