Effects of recombinant human growth hormone in severe neurosurgical patients: A single center, retrospective study.
<h4>Purpose</h4>To explore the effects of recombinant human growth hormone (r-hGH) on inflammatory mediators, immune cells and prognosis in severe neurosurgical patients.<h4>Methods</h4>From August 2020 to June 2021, a total of 236 patients who admitted to the neurosurgical i...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0317219 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841533219050094592 |
|---|---|
| author | Xixian Liao Haorun Huang Binghui Qiu Jiaping Chen An Zhang Haoxin Liang Chuanping Huang Fen Mei Jian Mao Fan Liu Ming Jin Xiaojie Peng Haidie Ma Wenjie Ding Songtao Qi Yun Bao |
| author_facet | Xixian Liao Haorun Huang Binghui Qiu Jiaping Chen An Zhang Haoxin Liang Chuanping Huang Fen Mei Jian Mao Fan Liu Ming Jin Xiaojie Peng Haidie Ma Wenjie Ding Songtao Qi Yun Bao |
| author_sort | Xixian Liao |
| collection | DOAJ |
| description | <h4>Purpose</h4>To explore the effects of recombinant human growth hormone (r-hGH) on inflammatory mediators, immune cells and prognosis in severe neurosurgical patients.<h4>Methods</h4>From August 2020 to June 2021, a total of 236 patients who admitted to the neurosurgical intensive care unit (NSICU) were retrospectively analyzed. The patients were divided into GH group (97 cases) and nGH group (139 cases) according to whether they received r-hGH treatment. Parameters including CD4+ T cell counts, inflammatory mediators and prognosis were recorded and assessed.<h4>Results</h4>The results showed that the cure time of pneumonia and intracranial infection in GH group patients was significantly shorter than in the nGH group (24.25 ± 4.89 days and 21.33 ± 1.53 days versus 29.13 ± 7.43 days and 25.17 ± 2.32 days, respectively). However, there was no significant difference in GOS scores between two groups (31.96% ≤ 3 and 68.04% > 3 vs 39.57% ≤ 3 and 60.43% > 3) (P = 0.232). Furthermore, the number of CD4+ T cells and CD8+ T cells in the GH group showed a significant upward trend. Last but not least, significant differences were also observed in IL-6 and IL-10 levels between two groups at days 1, 3, and 7.<h4>Conclusion</h4>The application of r-hGH in severe neurosurgical patients was effective in increasing the number of CD4+ T cells, down-regulating inflammatory mediators, shortening the cure time of pneumonia, intracranial infections and urinary tract infections, and improving patients' prognosis. |
| format | Article |
| id | doaj-art-26282e398d914d95b606ae79b0b1ccf3 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-26282e398d914d95b606ae79b0b1ccf32025-01-17T05:31:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031721910.1371/journal.pone.0317219Effects of recombinant human growth hormone in severe neurosurgical patients: A single center, retrospective study.Xixian LiaoHaorun HuangBinghui QiuJiaping ChenAn ZhangHaoxin LiangChuanping HuangFen MeiJian MaoFan LiuMing JinXiaojie PengHaidie MaWenjie DingSongtao QiYun Bao<h4>Purpose</h4>To explore the effects of recombinant human growth hormone (r-hGH) on inflammatory mediators, immune cells and prognosis in severe neurosurgical patients.<h4>Methods</h4>From August 2020 to June 2021, a total of 236 patients who admitted to the neurosurgical intensive care unit (NSICU) were retrospectively analyzed. The patients were divided into GH group (97 cases) and nGH group (139 cases) according to whether they received r-hGH treatment. Parameters including CD4+ T cell counts, inflammatory mediators and prognosis were recorded and assessed.<h4>Results</h4>The results showed that the cure time of pneumonia and intracranial infection in GH group patients was significantly shorter than in the nGH group (24.25 ± 4.89 days and 21.33 ± 1.53 days versus 29.13 ± 7.43 days and 25.17 ± 2.32 days, respectively). However, there was no significant difference in GOS scores between two groups (31.96% ≤ 3 and 68.04% > 3 vs 39.57% ≤ 3 and 60.43% > 3) (P = 0.232). Furthermore, the number of CD4+ T cells and CD8+ T cells in the GH group showed a significant upward trend. Last but not least, significant differences were also observed in IL-6 and IL-10 levels between two groups at days 1, 3, and 7.<h4>Conclusion</h4>The application of r-hGH in severe neurosurgical patients was effective in increasing the number of CD4+ T cells, down-regulating inflammatory mediators, shortening the cure time of pneumonia, intracranial infections and urinary tract infections, and improving patients' prognosis.https://doi.org/10.1371/journal.pone.0317219 |
| spellingShingle | Xixian Liao Haorun Huang Binghui Qiu Jiaping Chen An Zhang Haoxin Liang Chuanping Huang Fen Mei Jian Mao Fan Liu Ming Jin Xiaojie Peng Haidie Ma Wenjie Ding Songtao Qi Yun Bao Effects of recombinant human growth hormone in severe neurosurgical patients: A single center, retrospective study. PLoS ONE |
| title | Effects of recombinant human growth hormone in severe neurosurgical patients: A single center, retrospective study. |
| title_full | Effects of recombinant human growth hormone in severe neurosurgical patients: A single center, retrospective study. |
| title_fullStr | Effects of recombinant human growth hormone in severe neurosurgical patients: A single center, retrospective study. |
| title_full_unstemmed | Effects of recombinant human growth hormone in severe neurosurgical patients: A single center, retrospective study. |
| title_short | Effects of recombinant human growth hormone in severe neurosurgical patients: A single center, retrospective study. |
| title_sort | effects of recombinant human growth hormone in severe neurosurgical patients a single center retrospective study |
| url | https://doi.org/10.1371/journal.pone.0317219 |
| work_keys_str_mv | AT xixianliao effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT haorunhuang effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT binghuiqiu effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT jiapingchen effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT anzhang effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT haoxinliang effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT chuanpinghuang effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT fenmei effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT jianmao effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT fanliu effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT mingjin effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT xiaojiepeng effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT haidiema effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT wenjieding effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT songtaoqi effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy AT yunbao effectsofrecombinanthumangrowthhormoneinsevereneurosurgicalpatientsasinglecenterretrospectivestudy |