Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysis
IntroductionOsteoarthritis (OA) is a prevalent and debilitating disorder that affects the joints and has a complex array of causes. While sedentary behavior (SB) and physical activity (PA) have been implicated in OA risk, the relationship between these factors and OA development remains unclear. Thi...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1454185/full |
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| author | Jiangqin He Cao Zhang Lili Yang |
| author_facet | Jiangqin He Cao Zhang Lili Yang |
| author_sort | Jiangqin He |
| collection | DOAJ |
| description | IntroductionOsteoarthritis (OA) is a prevalent and debilitating disorder that affects the joints and has a complex array of causes. While sedentary behavior (SB) and physical activity (PA) have been implicated in OA risk, the relationship between these factors and OA development remains unclear. This study investigates the correlation and potential causality between SB, PA, and OA using both cross-sectional and Mendelian randomization (MR) analysis.MethodsWe conducted a two-phase study that included a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) and a MR analysis. A weighted analysis was performed on data from the NHANES to explore the relationship between SB, PA, and the risk of OA. Logistic regression was used to assess the association between SB, PA, and OA, adjusting for potential confounders. Non-parametric curve fitting was applied to examine the dose-response relationship between PA levels and OA onset. Additionally, MR was utilized to infer the genetic causality between SB, PA, and OA risk, using genetic instruments as proxies for SB and PA.ResultsThe final analysis, which included 24,738 participants, revealed that OA prevalence was 13.47%, with individuals diagnosed with OA exhibiting significantly higher levels of SB and lower levels of PA. A U-shaped relationship was observed between PA and OA risk, with a decrease in OA incidence as PA levels increased, although the protective effect of PA was less pronounced in individuals with severe SB. MR analysis indicated that genetically inferred SB was associated with a higher likelihood of OA (IVW OR 1.20, 95% CI 1.13–1.28), while increased PA was inversely associated with OA risk (IVW OR 0.85, 95% CI 0.73–0.98).ConclusionThis research emphasizes the significance of SB and PA as modifiable factors influencing the risk of OA. It is recommended that individuals at risk of OA should aim to participate in regular physical activity and minimize sedentary behavior to lower their risk of developing the disease. The MR analysis results support the potential causal impact of SB and PA on OA, providing valuable information for the development of therapeutic and rehabilitative strategies. |
| format | Article |
| id | doaj-art-2618e4d98c2b4903bdf7c84e656eb3b8 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-2618e4d98c2b4903bdf7c84e656eb3b82025-01-13T15:33:09ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-01-011210.3389/fpubh.2024.14541851454185Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysisJiangqin He0Cao Zhang1Lili Yang2Department of Nursing, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, ChinaDepartment of Anesthesia, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, ChinaDepartment of Nursing, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, ChinaIntroductionOsteoarthritis (OA) is a prevalent and debilitating disorder that affects the joints and has a complex array of causes. While sedentary behavior (SB) and physical activity (PA) have been implicated in OA risk, the relationship between these factors and OA development remains unclear. This study investigates the correlation and potential causality between SB, PA, and OA using both cross-sectional and Mendelian randomization (MR) analysis.MethodsWe conducted a two-phase study that included a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) and a MR analysis. A weighted analysis was performed on data from the NHANES to explore the relationship between SB, PA, and the risk of OA. Logistic regression was used to assess the association between SB, PA, and OA, adjusting for potential confounders. Non-parametric curve fitting was applied to examine the dose-response relationship between PA levels and OA onset. Additionally, MR was utilized to infer the genetic causality between SB, PA, and OA risk, using genetic instruments as proxies for SB and PA.ResultsThe final analysis, which included 24,738 participants, revealed that OA prevalence was 13.47%, with individuals diagnosed with OA exhibiting significantly higher levels of SB and lower levels of PA. A U-shaped relationship was observed between PA and OA risk, with a decrease in OA incidence as PA levels increased, although the protective effect of PA was less pronounced in individuals with severe SB. MR analysis indicated that genetically inferred SB was associated with a higher likelihood of OA (IVW OR 1.20, 95% CI 1.13–1.28), while increased PA was inversely associated with OA risk (IVW OR 0.85, 95% CI 0.73–0.98).ConclusionThis research emphasizes the significance of SB and PA as modifiable factors influencing the risk of OA. It is recommended that individuals at risk of OA should aim to participate in regular physical activity and minimize sedentary behavior to lower their risk of developing the disease. The MR analysis results support the potential causal impact of SB and PA on OA, providing valuable information for the development of therapeutic and rehabilitative strategies.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1454185/fullosteoarthritissedentary behaviorphysical activityMendelian randomizationNHANES |
| spellingShingle | Jiangqin He Cao Zhang Lili Yang Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysis Frontiers in Public Health osteoarthritis sedentary behavior physical activity Mendelian randomization NHANES |
| title | Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysis |
| title_full | Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysis |
| title_fullStr | Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysis |
| title_full_unstemmed | Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysis |
| title_short | Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysis |
| title_sort | association between sedentary behavior physical activity and osteoarthritis results from nhanes 2007 2020 and mendelian randomization analysis |
| topic | osteoarthritis sedentary behavior physical activity Mendelian randomization NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1454185/full |
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