Associations of gut microbiota with disease development, disease activity, and therapeutic effects in patients with systemic lupus erythematosus
Abstract Altered gut microbiota is linked to systemic lupus erythematosus (SLE), but its association with disease development, disease activity, and post-intervention changes remains unclear. We compared new-onset SLE (NOSLE, n = 25), SLE in remission (RemSLE, n = 30), and healthy controls (HC, n = ...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83835-0 |
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| author | Junko Nishio Hiroshi Sato Eri Watanabe Hiroaki Masuoka Kotaro Aoki Mai Kawazoe Risa Wakiya Soichi Yamada Sei Muraoka Shotaro Masuoka Tomoki Hayashi Satoshi Mizutani Zento Yamada Keiko Koshiba Izumi Irita Miwa Kanaji Karin Furukawa Nobuyuki Yajima Hiroaki Dobashi Wataru Hirose Yoshikazu Ishii Wataru Suda Toshihiro Nanki |
| author_facet | Junko Nishio Hiroshi Sato Eri Watanabe Hiroaki Masuoka Kotaro Aoki Mai Kawazoe Risa Wakiya Soichi Yamada Sei Muraoka Shotaro Masuoka Tomoki Hayashi Satoshi Mizutani Zento Yamada Keiko Koshiba Izumi Irita Miwa Kanaji Karin Furukawa Nobuyuki Yajima Hiroaki Dobashi Wataru Hirose Yoshikazu Ishii Wataru Suda Toshihiro Nanki |
| author_sort | Junko Nishio |
| collection | DOAJ |
| description | Abstract Altered gut microbiota is linked to systemic lupus erythematosus (SLE), but its association with disease development, disease activity, and post-intervention changes remains unclear. We compared new-onset SLE (NOSLE, n = 25), SLE in remission (RemSLE, n = 30), and healthy controls (HC, n = 30) cross-sectionally and conducted the first longitudinal analysis of NOSLE patients (n = 22) from pre-intervention to remission over 12 months. Significant β-diversity differences were observed in both NOSLE and RemSLE compared to HC, but not between NOSLE and RemSLE. Only four operational taxonomic units (OTUs) were enriched in NOSLE versus HC. However, 26 OTUs, including butyrate-producing bacteria (BPB), were depleted, and seven (including five BPBs) remained depleted in RemSLE compared to HC. OTUs positively and negatively correlated with disease activity were also identified. Longitudinal analysis revealed a reversal of several OTUs altered at onset and an increase in Streptococci, unrelated to the disease. Significant β-diversity differences were observed in patients with anti-SSA or anti-RNP antibodies and those with complement reduction compared to their counterparts. Our study identified gut microbiota alterations, including BPB depletion, in SLE regardless of onset or remission status, bacteria linked to disease activity, and a reversal of disease-associated bacteria along with the enrichment of Streptococci through intervention. |
| format | Article |
| id | doaj-art-260cfe1ee4374582845638ba496feb64 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-260cfe1ee4374582845638ba496feb642025-01-05T12:27:27ZengNature PortfolioScientific Reports2045-23222024-12-0114111610.1038/s41598-024-83835-0Associations of gut microbiota with disease development, disease activity, and therapeutic effects in patients with systemic lupus erythematosusJunko Nishio0Hiroshi Sato1Eri Watanabe2Hiroaki Masuoka3Kotaro Aoki4Mai Kawazoe5Risa Wakiya6Soichi Yamada7Sei Muraoka8Shotaro Masuoka9Tomoki Hayashi10Satoshi Mizutani11Zento Yamada12Keiko Koshiba13Izumi Irita14Miwa Kanaji15Karin Furukawa16Nobuyuki Yajima17Hiroaki Dobashi18Wataru Hirose19Yoshikazu Ishii20Wataru Suda21Toshihiro Nanki22Division of Rheumatology, Department of Internal Medicine, Toho University School of MedicineDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineRIKEN Center for Integrative Medical SciencesDepartment of Microbiology and Infectious Diseases, Toho University School of MedicineDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineDivision of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa UniversityDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineDivision of Rheumatology, Department of Medicine, Showa UniversityDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineDivision of Rheumatology, Department of Medicine, Showa UniversityDivision of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa UniversityHirose Clinic of RheumatologyDepartment of Microbiology and Infectious Diseases, Toho University School of MedicineRIKEN Center for Integrative Medical SciencesDivision of Rheumatology, Department of Internal Medicine, Toho University School of MedicineAbstract Altered gut microbiota is linked to systemic lupus erythematosus (SLE), but its association with disease development, disease activity, and post-intervention changes remains unclear. We compared new-onset SLE (NOSLE, n = 25), SLE in remission (RemSLE, n = 30), and healthy controls (HC, n = 30) cross-sectionally and conducted the first longitudinal analysis of NOSLE patients (n = 22) from pre-intervention to remission over 12 months. Significant β-diversity differences were observed in both NOSLE and RemSLE compared to HC, but not between NOSLE and RemSLE. Only four operational taxonomic units (OTUs) were enriched in NOSLE versus HC. However, 26 OTUs, including butyrate-producing bacteria (BPB), were depleted, and seven (including five BPBs) remained depleted in RemSLE compared to HC. OTUs positively and negatively correlated with disease activity were also identified. Longitudinal analysis revealed a reversal of several OTUs altered at onset and an increase in Streptococci, unrelated to the disease. Significant β-diversity differences were observed in patients with anti-SSA or anti-RNP antibodies and those with complement reduction compared to their counterparts. Our study identified gut microbiota alterations, including BPB depletion, in SLE regardless of onset or remission status, bacteria linked to disease activity, and a reversal of disease-associated bacteria along with the enrichment of Streptococci through intervention.https://doi.org/10.1038/s41598-024-83835-0Systemic lupus erythematosusGut microbiotaButyrate-producing bacteria[Eubacterium] rectaleHungatella effluviiStreptococcus |
| spellingShingle | Junko Nishio Hiroshi Sato Eri Watanabe Hiroaki Masuoka Kotaro Aoki Mai Kawazoe Risa Wakiya Soichi Yamada Sei Muraoka Shotaro Masuoka Tomoki Hayashi Satoshi Mizutani Zento Yamada Keiko Koshiba Izumi Irita Miwa Kanaji Karin Furukawa Nobuyuki Yajima Hiroaki Dobashi Wataru Hirose Yoshikazu Ishii Wataru Suda Toshihiro Nanki Associations of gut microbiota with disease development, disease activity, and therapeutic effects in patients with systemic lupus erythematosus Scientific Reports Systemic lupus erythematosus Gut microbiota Butyrate-producing bacteria [Eubacterium] rectale Hungatella effluvii Streptococcus |
| title | Associations of gut microbiota with disease development, disease activity, and therapeutic effects in patients with systemic lupus erythematosus |
| title_full | Associations of gut microbiota with disease development, disease activity, and therapeutic effects in patients with systemic lupus erythematosus |
| title_fullStr | Associations of gut microbiota with disease development, disease activity, and therapeutic effects in patients with systemic lupus erythematosus |
| title_full_unstemmed | Associations of gut microbiota with disease development, disease activity, and therapeutic effects in patients with systemic lupus erythematosus |
| title_short | Associations of gut microbiota with disease development, disease activity, and therapeutic effects in patients with systemic lupus erythematosus |
| title_sort | associations of gut microbiota with disease development disease activity and therapeutic effects in patients with systemic lupus erythematosus |
| topic | Systemic lupus erythematosus Gut microbiota Butyrate-producing bacteria [Eubacterium] rectale Hungatella effluvii Streptococcus |
| url | https://doi.org/10.1038/s41598-024-83835-0 |
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