Correlation between 25-hydroxyvitamin D level of lactating mothers and bone mineral density of infants and analysis of risk factors
Background: Aim was to demonstrate the influencing factors of infant bone mineral density (BMD) and its correlation with serum 25-hydroxyvitamin D (25-(OH)D) in nursing mothers. Methods: 200 children aged 0 č 1 years were rolled into normal group (n=120) and abnormal group (n=80) regarding the resul...
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Society of Medical Biochemists of Serbia, Belgrade
2024-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582406960J.pdf |
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| author | Jin Yan Li Minghui Ding Wei Wu Huiwen |
| author_facet | Jin Yan Li Minghui Ding Wei Wu Huiwen |
| author_sort | Jin Yan |
| collection | DOAJ |
| description | Background: Aim was to demonstrate the influencing factors of infant bone mineral density (BMD) and its correlation with serum 25-hydroxyvitamin D (25-(OH)D) in nursing mothers. Methods: 200 children aged 0 č 1 years were rolled into normal group (n=120) and abnormal group (n=80) regarding the results of ultrasound BMD examination. The sunshine duration of infants with different BMD and 25(OH)D, calcium and phosphorus levels of nursing mothers were analyzed, and univariate and multivariate analyses of BMD were implemented. Results: The results revealed that the sunshine duration and serum 25-(OH)D level of nursing mothers in abnormal group were inferior to those in normal group (P<0.05). Additionally, a notable positive correlation existed between sunshine duration, serum 25-(OH)D level of nursing mothers and BMD (r = 0.911 and 0.503, P<0.05). According to Logistic regression analysis, outdoor activity time 0 č 1 h/d, premature infants, and breastfeeding alone were independent risk factors (RFs) for abnormal BMD in infants, and vitamin D(VD) and calcium supplementation were independent protective factors (P<0.05). Conclusions: VD and calcium intake, adequate sunshine duration, mixed feeding, and increasing serum 25-(OH)D can reduce the occurrence of abnormal BMD in infants. |
| format | Article |
| id | doaj-art-25f3bfa909874e5f97a8537b00d8cd2b |
| institution | Kabale University |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-25f3bfa909874e5f97a8537b00d8cd2b2024-12-02T12:53:03ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662024-01-0143696096610.5937/jomb0-484711452-82582406960JCorrelation between 25-hydroxyvitamin D level of lactating mothers and bone mineral density of infants and analysis of risk factorsJin Yan0Li Minghui1Ding Wei2Wu Huiwen3Maternal and Child Health Hospital of Hubei Province, Department of Child Health, Wuhan, Hubei Province, ChinaMaternal and Child Health Hospital of Hubei Province, Department of Child Health, Wuhan, Hubei Province, ChinaMaternal and Child Health Hospital of Hubei Province, Department of Child Health, Wuhan, Hubei Province, ChinaMaternal and Child Health Hospital of Hubei Province, Department of Child Health, Wuhan, Hubei Province, ChinaBackground: Aim was to demonstrate the influencing factors of infant bone mineral density (BMD) and its correlation with serum 25-hydroxyvitamin D (25-(OH)D) in nursing mothers. Methods: 200 children aged 0 č 1 years were rolled into normal group (n=120) and abnormal group (n=80) regarding the results of ultrasound BMD examination. The sunshine duration of infants with different BMD and 25(OH)D, calcium and phosphorus levels of nursing mothers were analyzed, and univariate and multivariate analyses of BMD were implemented. Results: The results revealed that the sunshine duration and serum 25-(OH)D level of nursing mothers in abnormal group were inferior to those in normal group (P<0.05). Additionally, a notable positive correlation existed between sunshine duration, serum 25-(OH)D level of nursing mothers and BMD (r = 0.911 and 0.503, P<0.05). According to Logistic regression analysis, outdoor activity time 0 č 1 h/d, premature infants, and breastfeeding alone were independent risk factors (RFs) for abnormal BMD in infants, and vitamin D(VD) and calcium supplementation were independent protective factors (P<0.05). Conclusions: VD and calcium intake, adequate sunshine duration, mixed feeding, and increasing serum 25-(OH)D can reduce the occurrence of abnormal BMD in infants.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582406960J.pdfinfantsbone mineral densityserum 25hydroxyvitamin d (25-(oh)d)sunshine durationinfluencing factors |
| spellingShingle | Jin Yan Li Minghui Ding Wei Wu Huiwen Correlation between 25-hydroxyvitamin D level of lactating mothers and bone mineral density of infants and analysis of risk factors Journal of Medical Biochemistry infants bone mineral density serum 25hydroxyvitamin d (25-(oh)d) sunshine duration influencing factors |
| title | Correlation between 25-hydroxyvitamin D level of lactating mothers and bone mineral density of infants and analysis of risk factors |
| title_full | Correlation between 25-hydroxyvitamin D level of lactating mothers and bone mineral density of infants and analysis of risk factors |
| title_fullStr | Correlation between 25-hydroxyvitamin D level of lactating mothers and bone mineral density of infants and analysis of risk factors |
| title_full_unstemmed | Correlation between 25-hydroxyvitamin D level of lactating mothers and bone mineral density of infants and analysis of risk factors |
| title_short | Correlation between 25-hydroxyvitamin D level of lactating mothers and bone mineral density of infants and analysis of risk factors |
| title_sort | correlation between 25 hydroxyvitamin d level of lactating mothers and bone mineral density of infants and analysis of risk factors |
| topic | infants bone mineral density serum 25hydroxyvitamin d (25-(oh)d) sunshine duration influencing factors |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582406960J.pdf |
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