ALDH1A3 Contributes to Radiation-Induced Inhibition of Self-Renewal and Promotes Proliferative Activity of p53-Deficient Glioblastoma Stem Cells at the Onset of Differentiation

ALDH1A3 Contributes to Radiation-Induced Inhibition of Self-Renewal and Promotes Proliferative Activity of p53-Deficient Glioblastoma Stem Cells at the Onset of Differentiation

ALDH1A3 is a marker for mesenchymal glioblastomas characterized by a greater degree of aggressiveness compared to other major subtypes. ADH1A3 has been implicated in the regulation of stemness and radioresistance mediated by glioblastoma stem cells. Mechanisms by which ALDH1A3 promotes malignant pro...

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Bibliographic Details
Main Authors: Andreas Müller, Bogdan Lyubarskyy, Jurij Tchoumakov, Maike Wagner, Bettina Sprang, Florian Ringel, Ella L. Kim
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Cells
Subjects:
ALDH1A3
glioblastoma stem cells
radioresistance
Online Access:https://www.mdpi.com/2073-4409/13/21/1802
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