Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer

Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer

Abstract Background Nicastrin, a subunit of the γ-secretase complex, is encoded by the NCSTN gene and regulates notch signaling, it is involved in the pathogenesis of hidradenitis suppurativa (HS), Alzheimer disease (AD), and liver cancer. However, the animal models for studying HS are relatively sc...

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Main Authors: Lu Yan, Yin-Sen Song, Jian Zhou, Lin Zhu, Tian-Wei Shi, Hui-Qian Yu, Zi-Qing Dong, Wei Wang, Ting Long, Hao-Ying Liu, Zhe-Ye Shi, Jian-Guo Li
Format: Article
Language:English
Published: BMC 2024-12-01
Series:European Journal of Medical Research
Subjects:
Gene knockout mice
Hidradenitis suppurativa
NCSTN
Notch
Tamoxifen
Online Access:https://doi.org/10.1186/s40001-024-02225-4
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https://doi.org/10.1186/s40001-024-02225-4

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