DONOR KIR3DL1/RECEPTOR HLA-BW4-80I COMBINATION REDUCES ACUTE LEUKEMIA RELAPSE AFTER UMBILICAL CORD BLOOD TRANSPLANTATION WITHOUT IN VITRO T-CELL DEPLETION
Background: Donor natural killer (NK) cell alloreactivity in umbilical cord bone marrow transplantation (UCBT) can lead to leukemic relapse. However, NK cell function is calibrated by interaction with human leukocyte antigens (HLAs). This study aimed to investigate graft-resistant leukemia after tra...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2021-01-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/4363 |
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| author | xinchen fang Zimin Sun Huilan Liu Xiang Wan Wen Yao Kaidi Song Kaidi Song Baolin Tang Xiaoyu zhu Jun Peng |
| author_facet | xinchen fang Zimin Sun Huilan Liu Xiang Wan Wen Yao Kaidi Song Kaidi Song Baolin Tang Xiaoyu zhu Jun Peng |
| author_sort | xinchen fang |
| collection | DOAJ |
| description | Background: Donor natural killer (NK) cell alloreactivity in umbilical cord bone marrow transplantation (UCBT) can lead to leukemic relapse. However, NK cell function is calibrated by interaction with human leukocyte antigens (HLAs). This study aimed to investigate graft-resistant leukemia after transplantation and compared specific genotypes of killer immunoglobulin-like receptors (KIRs) in donors and human leukocyte antigen ligands in patients.
Methods: We retrospectively analyzed 232 patients with acute leukemia from a single center. Patients had undergone UCBT with myeloablative conditioning and without anti-thymocyte globulin. We identified the KIR genotypes of cord blood donors using polymerase chain reaction with sequence-specific primers. All of the donors contained KIR3DL1.
Results: The patients were divided into three groups according to the HLA-B locus. The donor KIR3DL1 and recipient HLA-Bw4-80I combination was predictive of being highly educated, and was associated with a lower relapse (P = 0.006) and better overall survival (probability of relapse = 0.13, P < 0.001) than the uneducated group. We found no significant increase in the incidence of acute or chronic graft-versus-host disease.
Conclusions: Our data suggest that the donor KIR3DL1/receptor and HLA-Bw4-80I combination in UCBT results in stronger graft-versus-leukemia effects and improved outcomes in patients with acute leukemia. |
| format | Article |
| id | doaj-art-2569576d7e904eb883a6a66b482e1cdd |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-2569576d7e904eb883a6a66b482e1cdd2025-01-02T10:37:18ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062021-01-0113110.4084/mjhid.2021.005DONOR KIR3DL1/RECEPTOR HLA-BW4-80I COMBINATION REDUCES ACUTE LEUKEMIA RELAPSE AFTER UMBILICAL CORD BLOOD TRANSPLANTATION WITHOUT IN VITRO T-CELL DEPLETIONxinchen fang0Zimin SunHuilan LiuXiang WanWen YaoKaidi SongKaidi SongBaolin TangXiaoyu zhuJun Penga:1:{s:5:"en_US";s:68:"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine";}Background: Donor natural killer (NK) cell alloreactivity in umbilical cord bone marrow transplantation (UCBT) can lead to leukemic relapse. However, NK cell function is calibrated by interaction with human leukocyte antigens (HLAs). This study aimed to investigate graft-resistant leukemia after transplantation and compared specific genotypes of killer immunoglobulin-like receptors (KIRs) in donors and human leukocyte antigen ligands in patients. Methods: We retrospectively analyzed 232 patients with acute leukemia from a single center. Patients had undergone UCBT with myeloablative conditioning and without anti-thymocyte globulin. We identified the KIR genotypes of cord blood donors using polymerase chain reaction with sequence-specific primers. All of the donors contained KIR3DL1. Results: The patients were divided into three groups according to the HLA-B locus. The donor KIR3DL1 and recipient HLA-Bw4-80I combination was predictive of being highly educated, and was associated with a lower relapse (P = 0.006) and better overall survival (probability of relapse = 0.13, P < 0.001) than the uneducated group. We found no significant increase in the incidence of acute or chronic graft-versus-host disease. Conclusions: Our data suggest that the donor KIR3DL1/receptor and HLA-Bw4-80I combination in UCBT results in stronger graft-versus-leukemia effects and improved outcomes in patients with acute leukemia.http://www.mjhid.org/index.php/mjhid/article/view/4363acute myeloid leukemia, natural killer cells, killer immunoglobulin-like receptors, umbilical cord blood transplantation，acute lymphocytic leukemia |
| spellingShingle | xinchen fang Zimin Sun Huilan Liu Xiang Wan Wen Yao Kaidi Song Kaidi Song Baolin Tang Xiaoyu zhu Jun Peng DONOR KIR3DL1/RECEPTOR HLA-BW4-80I COMBINATION REDUCES ACUTE LEUKEMIA RELAPSE AFTER UMBILICAL CORD BLOOD TRANSPLANTATION WITHOUT IN VITRO T-CELL DEPLETION Mediterranean Journal of Hematology and Infectious Diseases acute myeloid leukemia, natural killer cells, killer immunoglobulin-like receptors, umbilical cord blood transplantation，acute lymphocytic leukemia |
| title | DONOR KIR3DL1/RECEPTOR HLA-BW4-80I COMBINATION REDUCES ACUTE LEUKEMIA RELAPSE AFTER UMBILICAL CORD BLOOD TRANSPLANTATION WITHOUT IN VITRO T-CELL DEPLETION |
| title_full | DONOR KIR3DL1/RECEPTOR HLA-BW4-80I COMBINATION REDUCES ACUTE LEUKEMIA RELAPSE AFTER UMBILICAL CORD BLOOD TRANSPLANTATION WITHOUT IN VITRO T-CELL DEPLETION |
| title_fullStr | DONOR KIR3DL1/RECEPTOR HLA-BW4-80I COMBINATION REDUCES ACUTE LEUKEMIA RELAPSE AFTER UMBILICAL CORD BLOOD TRANSPLANTATION WITHOUT IN VITRO T-CELL DEPLETION |
| title_full_unstemmed | DONOR KIR3DL1/RECEPTOR HLA-BW4-80I COMBINATION REDUCES ACUTE LEUKEMIA RELAPSE AFTER UMBILICAL CORD BLOOD TRANSPLANTATION WITHOUT IN VITRO T-CELL DEPLETION |
| title_short | DONOR KIR3DL1/RECEPTOR HLA-BW4-80I COMBINATION REDUCES ACUTE LEUKEMIA RELAPSE AFTER UMBILICAL CORD BLOOD TRANSPLANTATION WITHOUT IN VITRO T-CELL DEPLETION |
| title_sort | donor kir3dl1 receptor hla bw4 80i combination reduces acute leukemia relapse after umbilical cord blood transplantation without in vitro t cell depletion |
| topic | acute myeloid leukemia, natural killer cells, killer immunoglobulin-like receptors, umbilical cord blood transplantation，acute lymphocytic leukemia |
| url | http://www.mjhid.org/index.php/mjhid/article/view/4363 |
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