Effect of ginsenoside fermented by Pediococcus acidilactici XM-06 on preventing diarrhea in mice via regulating intestinal barrier function and gut microbiota
Ginsenosides has been extensively used in clinical settings to treat various inflammatory diseases. At present, the anti-inflammatory effect of ginsenosides is mainly focused on monomeric ginsenosides, while the total saponins of ginseng and their synergistic effect with probiotic fermentation produ...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624005978 |
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| author | Wen-Man Xu Qi Liu Si-Yao Fan Zi-Xin Wang Shi-Rui Lu Jie Liu Hong-Jie Piao Wenxiu Ji Wei-Wei Dong |
| author_facet | Wen-Man Xu Qi Liu Si-Yao Fan Zi-Xin Wang Shi-Rui Lu Jie Liu Hong-Jie Piao Wenxiu Ji Wei-Wei Dong |
| author_sort | Wen-Man Xu |
| collection | DOAJ |
| description | Ginsenosides has been extensively used in clinical settings to treat various inflammatory diseases. At present, the anti-inflammatory effect of ginsenosides is mainly focused on monomeric ginsenosides, while the total saponins of ginseng and their synergistic effect with probiotic fermentation products are rarely studied. This study aimed to investigate the mitigative effects of fermented ginsenosides with Pediococcus acidilactici on Enterotoxigenic Escherichia coli diarrhea in mice. P. acidilactici XM-06 and ginsenoside fermentation products demonstrated significant pre-protection against ETEC-induced diarrhea by mitigating inflammation, inhibited the ERK and upregulated the Z0–1, 0ccludin and Claudin-1 levels, and reducing oxidative stress. These products not only repaired intestinal mucosal damage caused by ETEC-induced diarrhea in mice but also positively influenced gut microbiota dysbiosis by increasing the abundance of Lactobacillus and Bacteroides while decreasing the abundance of Enterobacter, potentially providing a new natural product for the prevention of ETEC-associated diarrheal diseases in humans. |
| format | Article |
| id | doaj-art-2562bb6ffc144e1cbcd1e84736b17ed9 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-2562bb6ffc144e1cbcd1e84736b17ed92024-12-14T06:30:17ZengElsevierJournal of Functional Foods1756-46462024-12-01123106594Effect of ginsenoside fermented by Pediococcus acidilactici XM-06 on preventing diarrhea in mice via regulating intestinal barrier function and gut microbiotaWen-Man Xu0Qi Liu1Si-Yao Fan2Zi-Xin Wang3Shi-Rui Lu4Jie Liu5Hong-Jie Piao6Wenxiu Ji7Wei-Wei Dong8College of Agriculture, Yanbian University, Jilin, Yanji 133002, ChinaCollege of Agriculture, Yanbian University, Jilin, Yanji 133002, ChinaCollege of Agriculture, Yanbian University, Jilin, Yanji 133002, ChinaCollege of Agriculture, Yanbian University, Jilin, Yanji 133002, ChinaCollege of Agriculture, Yanbian University, Jilin, Yanji 133002, ChinaJilin Huang Zhi Huang Biotechnology Co., Ltd., Jilin, Yanji 133002, ChinaCollege of Agriculture, Yanbian University, Jilin, Yanji 133002, China; Corresponding author at: Yanbian University, Park Road 977, Yanji City, Jilin Province 133002, China.College of Agriculture, Yanbian University, Jilin, Yanji 133002, China; Corresponding author at: Yanbian University, Park Road 977, Yanji City, Jilin Province 133002, China.College of Agriculture, Yanbian University, Jilin, Yanji 133002, China; Corresponding author at: Yanbian University, Park Road 977, Yanji City, Jilin Province 133002, China.Ginsenosides has been extensively used in clinical settings to treat various inflammatory diseases. At present, the anti-inflammatory effect of ginsenosides is mainly focused on monomeric ginsenosides, while the total saponins of ginseng and their synergistic effect with probiotic fermentation products are rarely studied. This study aimed to investigate the mitigative effects of fermented ginsenosides with Pediococcus acidilactici on Enterotoxigenic Escherichia coli diarrhea in mice. P. acidilactici XM-06 and ginsenoside fermentation products demonstrated significant pre-protection against ETEC-induced diarrhea by mitigating inflammation, inhibited the ERK and upregulated the Z0–1, 0ccludin and Claudin-1 levels, and reducing oxidative stress. These products not only repaired intestinal mucosal damage caused by ETEC-induced diarrhea in mice but also positively influenced gut microbiota dysbiosis by increasing the abundance of Lactobacillus and Bacteroides while decreasing the abundance of Enterobacter, potentially providing a new natural product for the prevention of ETEC-associated diarrheal diseases in humans.http://www.sciencedirect.com/science/article/pii/S1756464624005978Enterotoxigenic Escherichia coliFermentationGinsenosidesGut microbiotaPediococcus acidilactici |
| spellingShingle | Wen-Man Xu Qi Liu Si-Yao Fan Zi-Xin Wang Shi-Rui Lu Jie Liu Hong-Jie Piao Wenxiu Ji Wei-Wei Dong Effect of ginsenoside fermented by Pediococcus acidilactici XM-06 on preventing diarrhea in mice via regulating intestinal barrier function and gut microbiota Journal of Functional Foods Enterotoxigenic Escherichia coli Fermentation Ginsenosides Gut microbiota Pediococcus acidilactici |
| title | Effect of ginsenoside fermented by Pediococcus acidilactici XM-06 on preventing diarrhea in mice via regulating intestinal barrier function and gut microbiota |
| title_full | Effect of ginsenoside fermented by Pediococcus acidilactici XM-06 on preventing diarrhea in mice via regulating intestinal barrier function and gut microbiota |
| title_fullStr | Effect of ginsenoside fermented by Pediococcus acidilactici XM-06 on preventing diarrhea in mice via regulating intestinal barrier function and gut microbiota |
| title_full_unstemmed | Effect of ginsenoside fermented by Pediococcus acidilactici XM-06 on preventing diarrhea in mice via regulating intestinal barrier function and gut microbiota |
| title_short | Effect of ginsenoside fermented by Pediococcus acidilactici XM-06 on preventing diarrhea in mice via regulating intestinal barrier function and gut microbiota |
| title_sort | effect of ginsenoside fermented by pediococcus acidilactici xm 06 on preventing diarrhea in mice via regulating intestinal barrier function and gut microbiota |
| topic | Enterotoxigenic Escherichia coli Fermentation Ginsenosides Gut microbiota Pediococcus acidilactici |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624005978 |
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