Amino acid deprivation in cancer cells with compensatory autophagy induction increases sensitivity to autophagy inhibitors

Amino acid deprivation in cancer cells with compensatory autophagy induction increases sensitivity to autophagy inhibitors

Inhibition of autophagy is an important strategy in cancer therapy. However, prolonged inhibition of certain autophagies in established cancer cells may increase therapeutic resistance, though the underlying mechanisms of its induction and enhancement remain unclear. This study sought to elucidate t...

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Bibliographic Details
Main Authors: Takahito Fukui, Manami Yabumoto, Misuzu Nishida, Shiori Hirokawa, Riho Sato, Taichi Kurisu, Miyu Nakai, Md. Abul Hassan, Koji Kishimoto
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Molecular & Cellular Oncology
Subjects:
Amino acid deprivation
amino acid transporter
autophagy
cancer
chemoresistance
Online Access:https://www.tandfonline.com/doi/10.1080/23723556.2024.2377404
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