Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization
Recent cohort studies suggest a potential association between atopic dermatitis and dementia, though the evidence remains conflicting. This study aims to elucidate the association between atopic dermatitis and dementia employing systematic review, meta-analysis, and Mendelian randomization (MR). A c...
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Medical Journals Sweden
2025-01-01
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| Series: | Acta Dermato-Venereologica |
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| Online Access: | https://medicaljournalssweden.se/actadv/article/view/41321 |
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| author | Yeon-Su Gwak Seo-Yeon Kim Chae-Eon Woo Kihyuk Shin Eunjeong Son Jin-Woo Kim Sung-Jin Kim Tae-Jin Song Hae Ryoun Park Kihun Kim Dai Sik Ko Yun Hak Kim |
| author_facet | Yeon-Su Gwak Seo-Yeon Kim Chae-Eon Woo Kihyuk Shin Eunjeong Son Jin-Woo Kim Sung-Jin Kim Tae-Jin Song Hae Ryoun Park Kihun Kim Dai Sik Ko Yun Hak Kim |
| author_sort | Yeon-Su Gwak |
| collection | DOAJ |
| description | Recent cohort studies suggest a potential association between atopic dermatitis and dementia, though the evidence remains conflicting. This study aims to elucidate the association between atopic dermatitis and dementia employing systematic review, meta-analysis, and Mendelian randomization (MR). A comprehensive search was performed to select eligible cohort studies using Medline, Embase, Scopus, ScienceDirect, and the Web of Science database. In MR analysis, genomic data from the Genome Wide Association Study (GWAS) (864,982 European individuals) for atopic dermatitis cases and dementia cases were obtained from the MRBase. Statistical analyses included the inverse-variance weighted (IVW) method, sensitivity tests, and MR-PRESSO for outliers. The adjustment accounted for various factors, including sex, age, smoking status, and other medical comorbidities, along with several additional variables. In the systematic review and meta-analysis, 5 longitudinal cohort studies (12,576,235 participants) indicated a significant association between atopic dermatitis and all-cause dementia (adjusted hazard ratio: 1.15, 95% CI: 1.07–1.23). Subgroup analyses revealed an adjusted hazard ratio of 1.18 (95% CI: 1.08–1.27) for Alzheimer’s disease in patients with atopic dermatitis, and an adjusted hazard ratio of 1.37 (95% CI: 1.21–1.55) for all-cause dementia in patients with moderate-to-severe atopic dermatitis. However, MR analysis showed no significant causal link between atopic dermatitis and dementia, Alzheimer’s disease, vascular dementia, or cognitive performance. While the meta-analysis revealed a significant association, MR analysis did not substantiate a significant causal link. Future research should consider demographic variables and medication influences in unravelling the intricate atopic dermatitis–dementia interplay.
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| format | Article |
| id | doaj-art-255b570d277c410c933b42692f7ffc95 |
| institution | Kabale University |
| issn | 0001-5555 1651-2057 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj-art-255b570d277c410c933b42692f7ffc952025-01-03T08:46:03ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572025-01-0110510.2340/actadv.v105.41321Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian RandomizationYeon-Su Gwak0Seo-Yeon Kim1Chae-Eon Woo2Kihyuk Shin3Eunjeong Son4Jin-Woo Kim5Sung-Jin Kim6Tae-Jin Song7Hae Ryoun Park8Kihun Kim9Dai Sik Ko10Yun Hak Kim11School of Medicine, Pusan National University, Yangsan, Republic of KoreaSchool of Medicine, Pusan National University, Yangsan, Republic of KoreaSchool of Medicine, Pusan National University, Yangsan, Republic of KoreaDepartment of Dermatology, College of Medicine, Pusan National University, Busan, Korea; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Busan, KoreaDivision of Respiratory and Allergy, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of KoreaDepartment of Oral and Maxillofacial Surgery, Research Institute for Intractable Osteonecrosis of the Jaw, Ewha Womans University College of Medicine, Seoul, Republic of KoreaDepartment of Oral Histology and Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of KoreaDepartment of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Republic of KoreaDepartment of Periodontology and Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea; Periodontal Disease Signaling Network Research Center, School of Dentistry, Pusan National University, Yangsan, Republic of Korea; Department of Oral Pathology, Dental and Life Science Institute, Pusan National University, Yangsan, Republic of KoreaDepartment of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea; Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of KoreaDivision of Vascular Surgery, Department of General Surgery, Gachon University College of Medicine, Gil Medical Center, Incheon, Republic of KoreaDepartment of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea; Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of KoreaRecent cohort studies suggest a potential association between atopic dermatitis and dementia, though the evidence remains conflicting. This study aims to elucidate the association between atopic dermatitis and dementia employing systematic review, meta-analysis, and Mendelian randomization (MR). A comprehensive search was performed to select eligible cohort studies using Medline, Embase, Scopus, ScienceDirect, and the Web of Science database. In MR analysis, genomic data from the Genome Wide Association Study (GWAS) (864,982 European individuals) for atopic dermatitis cases and dementia cases were obtained from the MRBase. Statistical analyses included the inverse-variance weighted (IVW) method, sensitivity tests, and MR-PRESSO for outliers. The adjustment accounted for various factors, including sex, age, smoking status, and other medical comorbidities, along with several additional variables. In the systematic review and meta-analysis, 5 longitudinal cohort studies (12,576,235 participants) indicated a significant association between atopic dermatitis and all-cause dementia (adjusted hazard ratio: 1.15, 95% CI: 1.07–1.23). Subgroup analyses revealed an adjusted hazard ratio of 1.18 (95% CI: 1.08–1.27) for Alzheimer’s disease in patients with atopic dermatitis, and an adjusted hazard ratio of 1.37 (95% CI: 1.21–1.55) for all-cause dementia in patients with moderate-to-severe atopic dermatitis. However, MR analysis showed no significant causal link between atopic dermatitis and dementia, Alzheimer’s disease, vascular dementia, or cognitive performance. While the meta-analysis revealed a significant association, MR analysis did not substantiate a significant causal link. Future research should consider demographic variables and medication influences in unravelling the intricate atopic dermatitis–dementia interplay. https://medicaljournalssweden.se/actadv/article/view/41321atopic dermatitisdementiaAlzheimer's diseasesystematic reviewmeta-analysisMendelian randomization |
| spellingShingle | Yeon-Su Gwak Seo-Yeon Kim Chae-Eon Woo Kihyuk Shin Eunjeong Son Jin-Woo Kim Sung-Jin Kim Tae-Jin Song Hae Ryoun Park Kihun Kim Dai Sik Ko Yun Hak Kim Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization Acta Dermato-Venereologica atopic dermatitis dementia Alzheimer's disease systematic review meta-analysis Mendelian randomization |
| title | Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization |
| title_full | Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization |
| title_fullStr | Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization |
| title_full_unstemmed | Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization |
| title_short | Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization |
| title_sort | association between atopic dermatitis and dementia evidence from systematic review meta analysis and mendelian randomization |
| topic | atopic dermatitis dementia Alzheimer's disease systematic review meta-analysis Mendelian randomization |
| url | https://medicaljournalssweden.se/actadv/article/view/41321 |
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