Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis
Lung cancer, one of the most prevalent tumors, remains a clinical challenge with a poor five-year survival rate. Daurisoline, a bis-benzylisoquinoline alkaloid derived from the traditional Chinese herb Menispermum dauricum, is known to suppress tumor growth effectively. However, its precise mechanis...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Cancer Biology & Therapy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2024.2442556 |
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| author | Shi-Ming Tan Lan Luo Yi-Fu He Wei Li Xin-Xing Wan |
| author_facet | Shi-Ming Tan Lan Luo Yi-Fu He Wei Li Xin-Xing Wan |
| author_sort | Shi-Ming Tan |
| collection | DOAJ |
| description | Lung cancer, one of the most prevalent tumors, remains a clinical challenge with a poor five-year survival rate. Daurisoline, a bis-benzylisoquinoline alkaloid derived from the traditional Chinese herb Menispermum dauricum, is known to suppress tumor growth effectively. However, its precise mechanism of action remains unclear. In this study, we demonstrate that Daurisoline targets glycolysis and reduces the protein level of HK2, thereby inhibiting lung cancer progression. Mechanistic investigations reveal that Daurisoline directly binds to AKT and antagonizes the AKT-GSK3β-c-Myc-HK2 signaling axis. Furthermore, in an animal model, we validate the in vivo anti-tumor effect of Daurisoline without any observable side effects. Overall, our findings suggest that Daurisoline holds potential as an anti-tumor agent through its targeting of glycolysis. |
| format | Article |
| id | doaj-art-2551db47248045e1aa31b574beca8e2e |
| institution | Kabale University |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-2551db47248045e1aa31b574beca8e2e2024-12-19T14:32:20ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762025-12-0126110.1080/15384047.2024.2442556Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axisShi-Ming Tan0Lan Luo1Yi-Fu He2Wei Li3Xin-Xing Wan4Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Obstetrics and Gynecology, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Endocrinology, The Third Xiangya Hospital, Central South University, Changsha, ChinaLung cancer, one of the most prevalent tumors, remains a clinical challenge with a poor five-year survival rate. Daurisoline, a bis-benzylisoquinoline alkaloid derived from the traditional Chinese herb Menispermum dauricum, is known to suppress tumor growth effectively. However, its precise mechanism of action remains unclear. In this study, we demonstrate that Daurisoline targets glycolysis and reduces the protein level of HK2, thereby inhibiting lung cancer progression. Mechanistic investigations reveal that Daurisoline directly binds to AKT and antagonizes the AKT-GSK3β-c-Myc-HK2 signaling axis. Furthermore, in an animal model, we validate the in vivo anti-tumor effect of Daurisoline without any observable side effects. Overall, our findings suggest that Daurisoline holds potential as an anti-tumor agent through its targeting of glycolysis.https://www.tandfonline.com/doi/10.1080/15384047.2024.2442556Lung cancerdaurisolineAKTHK2 |
| spellingShingle | Shi-Ming Tan Lan Luo Yi-Fu He Wei Li Xin-Xing Wan Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis Cancer Biology & Therapy Lung cancer daurisoline AKT HK2 |
| title | Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis |
| title_full | Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis |
| title_fullStr | Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis |
| title_full_unstemmed | Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis |
| title_short | Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis |
| title_sort | daurisoline inhibits glycolysis of lung cancer by targeting the akt hk2 axis |
| topic | Lung cancer daurisoline AKT HK2 |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2024.2442556 |
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