Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults
Abstract Background As the prevalence of metabolic syndrome (MetS) rises among older adults, the associated risks of cardiovascular diseases and diabetes significantly increase, and it is closely linked to various metabolic processes in the body. Dysregulation of tryptophan (TRP) metabolism, particu...
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BMC
2025-01-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-024-01826-8 |
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| author | Shujing Sun Fangting Hu Yanru Sang Sheng Wang Xuechun Liu Jiafeng Shi Hongjuan Cao Fangbiao Tao Kaiyong Liu |
| author_facet | Shujing Sun Fangting Hu Yanru Sang Sheng Wang Xuechun Liu Jiafeng Shi Hongjuan Cao Fangbiao Tao Kaiyong Liu |
| author_sort | Shujing Sun |
| collection | DOAJ |
| description | Abstract Background As the prevalence of metabolic syndrome (MetS) rises among older adults, the associated risks of cardiovascular diseases and diabetes significantly increase, and it is closely linked to various metabolic processes in the body. Dysregulation of tryptophan (TRP) metabolism, particularly alterations in the kynurenine (KYN) and serotonin pathways, has been linked to the onset of chronic inflammation, oxidative stress, and insulin resistance, key contributors to the development of MetS. We aim to investigate the relationship between the TRP metabolites and the risk of MetS in older adults. Methods Ultra-performance liquid chromatography tandem mass spectrometry was used to detect TRP and its seven metabolites in a study involving 986 participants. Physical examination included the following indicators: blood pressure, body mass index, triglyceride levels, and high-density lipoprotein cholesterol (HDL-C) levels. Multiple linear regression, restricted cubic spline curve, binary logistic analysis, and sex-stratified analysis were used to explore the relationship between the metabolites and the risk of MetS in older adults. Results The results indicated that, after adjusting for covariates, higher levels of TRP, KYN, kynurenic acid (KA), and xanthurenic acid (XA) were risk factors for MetS (P for trend < 0.05). By contrast, higher ratios of 5-hydroxytryptamine to TRP and indole-3-propionic acid to TRP were protective factors against MetS (P for trend < 0.05). Conclusions TRP and its metabolites may serve as potential indicators for assessing and managing MetS in older adults, complementing existing biomarkers. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-253c03f24a5b4e7c8a91e8e9200de1c8 |
| institution | Kabale University |
| issn | 1472-6823 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-253c03f24a5b4e7c8a91e8e9200de1c82025-01-12T12:27:06ZengBMCBMC Endocrine Disorders1472-68232025-01-0125111110.1186/s12902-024-01826-8Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adultsShujing Sun0Fangting Hu1Yanru Sang2Sheng Wang3Xuechun Liu4Jiafeng Shi5Hongjuan Cao6Fangbiao Tao7Kaiyong Liu8School of Public Health, Anhui Medical UniversitySchool of Public Health, Anhui Medical UniversitySchool of Public Health, Anhui Medical UniversityCenter for Scientific Research, Anhui Medical UniversityHefei Hospital affiliated to Anhui Medical University (Hefei Second People’s Hospital)School of Public Health, Anhui Medical UniversityLu’an Center of Disease Control and PreventionSchool of Public Health, Anhui Medical UniversitySchool of Public Health, Anhui Medical UniversityAbstract Background As the prevalence of metabolic syndrome (MetS) rises among older adults, the associated risks of cardiovascular diseases and diabetes significantly increase, and it is closely linked to various metabolic processes in the body. Dysregulation of tryptophan (TRP) metabolism, particularly alterations in the kynurenine (KYN) and serotonin pathways, has been linked to the onset of chronic inflammation, oxidative stress, and insulin resistance, key contributors to the development of MetS. We aim to investigate the relationship between the TRP metabolites and the risk of MetS in older adults. Methods Ultra-performance liquid chromatography tandem mass spectrometry was used to detect TRP and its seven metabolites in a study involving 986 participants. Physical examination included the following indicators: blood pressure, body mass index, triglyceride levels, and high-density lipoprotein cholesterol (HDL-C) levels. Multiple linear regression, restricted cubic spline curve, binary logistic analysis, and sex-stratified analysis were used to explore the relationship between the metabolites and the risk of MetS in older adults. Results The results indicated that, after adjusting for covariates, higher levels of TRP, KYN, kynurenic acid (KA), and xanthurenic acid (XA) were risk factors for MetS (P for trend < 0.05). By contrast, higher ratios of 5-hydroxytryptamine to TRP and indole-3-propionic acid to TRP were protective factors against MetS (P for trend < 0.05). Conclusions TRP and its metabolites may serve as potential indicators for assessing and managing MetS in older adults, complementing existing biomarkers. Clinical trial number Not applicable.https://doi.org/10.1186/s12902-024-01826-8Metabolic syndromeTryptophanMetabolismOlder adults |
| spellingShingle | Shujing Sun Fangting Hu Yanru Sang Sheng Wang Xuechun Liu Jiafeng Shi Hongjuan Cao Fangbiao Tao Kaiyong Liu Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults BMC Endocrine Disorders Metabolic syndrome Tryptophan Metabolism Older adults |
| title | Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults |
| title_full | Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults |
| title_fullStr | Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults |
| title_full_unstemmed | Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults |
| title_short | Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults |
| title_sort | dysregulated tryptophan metabolism contributes to metabolic syndrome in chinese community dwelling older adults |
| topic | Metabolic syndrome Tryptophan Metabolism Older adults |
| url | https://doi.org/10.1186/s12902-024-01826-8 |
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