Multiorgan ultrastructural changes in rats induced in synthetic torpor
Torpor is a state used by several mammals to survive harsh winters and avoid predation, characterized by a drastic reduction in metabolic rate followed by a decrease in body temperature, heart rate, and many physiological variables. During torpor, all organs and systems must adapt to the new low-ene...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1451644/full |
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| author | Sara Salucci Timna Hitrec Emiliana Piscitiello Alessandra Occhinegro Luca Alberti Ludovico Taddei Sabrina Burattini Marco Luppi Domenico Tupone Roberto Amici Irene Faenza Matteo Cerri |
| author_facet | Sara Salucci Timna Hitrec Emiliana Piscitiello Alessandra Occhinegro Luca Alberti Ludovico Taddei Sabrina Burattini Marco Luppi Domenico Tupone Roberto Amici Irene Faenza Matteo Cerri |
| author_sort | Sara Salucci |
| collection | DOAJ |
| description | Torpor is a state used by several mammals to survive harsh winters and avoid predation, characterized by a drastic reduction in metabolic rate followed by a decrease in body temperature, heart rate, and many physiological variables. During torpor, all organs and systems must adapt to the new low-energy expenditure conditions to preserve physiological homeostasis. These adaptations may be exploited in a translational perspective in several fields. Recently, many features of torpor were shown to be mimicked in non-hibernators by the inhibition of neurons within the brainstem region of the Raphe Pallidus. The physiological resemblance of this artificial state, called synthetic torpor, with natural torpor has so far been described only in physiological terms, but no data have been shown regarding the induced morphological changes. Here, we show the first description of the ultrastructural changes in the liver, kidney, lung, skeletal muscle, and testis induced by a 6-hours inhibition of Raphe Pallidus neurons in a non-hibernating species, the rat. |
| format | Article |
| id | doaj-art-2532a12121f74b0ba354d6b9e8c95ec9 |
| institution | Kabale University |
| issn | 1664-042X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-2532a12121f74b0ba354d6b9e8c95ec92024-11-19T06:15:16ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2024-11-011510.3389/fphys.2024.14516441451644Multiorgan ultrastructural changes in rats induced in synthetic torporSara Salucci0Timna Hitrec1Emiliana Piscitiello2Alessandra Occhinegro3Luca Alberti4Ludovico Taddei5Sabrina Burattini6Marco Luppi7Domenico Tupone8Roberto Amici9Irene Faenza10Matteo Cerri11Department of Biomedical and Neuromotor Sciences – University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences – University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences – University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences – University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences – University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences – University of Bologna, Bologna, ItalyDepartment of Biomolecular Sciences, Carlo Bo Urbino University, Urbino, ItalyDepartment of Biomedical and Neuromotor Sciences – University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences – University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences – University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences – University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences – University of Bologna, Bologna, ItalyTorpor is a state used by several mammals to survive harsh winters and avoid predation, characterized by a drastic reduction in metabolic rate followed by a decrease in body temperature, heart rate, and many physiological variables. During torpor, all organs and systems must adapt to the new low-energy expenditure conditions to preserve physiological homeostasis. These adaptations may be exploited in a translational perspective in several fields. Recently, many features of torpor were shown to be mimicked in non-hibernators by the inhibition of neurons within the brainstem region of the Raphe Pallidus. The physiological resemblance of this artificial state, called synthetic torpor, with natural torpor has so far been described only in physiological terms, but no data have been shown regarding the induced morphological changes. Here, we show the first description of the ultrastructural changes in the liver, kidney, lung, skeletal muscle, and testis induced by a 6-hours inhibition of Raphe Pallidus neurons in a non-hibernating species, the rat.https://www.frontiersin.org/articles/10.3389/fphys.2024.1451644/fulltorporsynthetic torporelectron microscopyhypothermiaraphe pallidusliver |
| spellingShingle | Sara Salucci Timna Hitrec Emiliana Piscitiello Alessandra Occhinegro Luca Alberti Ludovico Taddei Sabrina Burattini Marco Luppi Domenico Tupone Roberto Amici Irene Faenza Matteo Cerri Multiorgan ultrastructural changes in rats induced in synthetic torpor Frontiers in Physiology torpor synthetic torpor electron microscopy hypothermia raphe pallidus liver |
| title | Multiorgan ultrastructural changes in rats induced in synthetic torpor |
| title_full | Multiorgan ultrastructural changes in rats induced in synthetic torpor |
| title_fullStr | Multiorgan ultrastructural changes in rats induced in synthetic torpor |
| title_full_unstemmed | Multiorgan ultrastructural changes in rats induced in synthetic torpor |
| title_short | Multiorgan ultrastructural changes in rats induced in synthetic torpor |
| title_sort | multiorgan ultrastructural changes in rats induced in synthetic torpor |
| topic | torpor synthetic torpor electron microscopy hypothermia raphe pallidus liver |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1451644/full |
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