Leveraging large-scale multi-omics evidences to identify therapeutic targets from genome-wide association studies

Leveraging large-scale multi-omics evidences to identify therapeutic targets from genome-wide association studies

Abstract Background Therapeutic targets supported by genetic evidence from genome-wide association studies (GWAS) show higher probability of success in clinical trials. GWAS is a powerful approach to identify links between genetic variants and phenotypic variation; however, identifying the genes dri...

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Main Authors: Samuel Lessard, Michael Chao, Kadri Reis, FinnGen, Estonian Biobank Research Team, Mathieu Beauvais, Deepak K. Rajpal, Jennifer Sloane, Priit Palta, Katherine Klinger, Emanuele de Rinaldis, Khader Shameer, Clément Chatelain
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Genomics
Subjects:
Genome-wide association study
Molecular quantitative trait loci
Causal inference
Therapeutic targets
Interleukin 6
Polymyalgia rheumatica
Online Access:https://doi.org/10.1186/s12864-024-10971-2
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https://doi.org/10.1186/s12864-024-10971-2

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