High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients

High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients

Abstract Background Microsatellite instability (MSI) is a well-established predictive biomarker for immune checkpoint inhibitor (ICI) response in metastatic colon cancer. Both high MSI and tumor mutational burden (TMB) are markers of genomic instability. However, the prognostic and predictive value...

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Main Authors: Annabella Di Mauro, Mariachiara Santorsola, Giovanni Savarese, Roberto Sirica, Monica Ianniello, Alessia Maria Cossu, Anna Ceccarelli, Francesco Sabbatino, Marco Bocchetti, Anna Chiara Carratù, Francesca Pentimalli, Gerardo Ferrara, Guglielmo Nasti, Michele Caraglia, Alessandro Ottaiano
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
Microsatellite instability
Tumor mutational burden
Colon cancer
Prognosis
NGS
Online Access:https://doi.org/10.1186/s12967-024-05927-9
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