Tuberculosis in Goats and Sheep in Afar Pastoral Region of Ethiopia and Isolation of Mycobacterium tuberculosis from Goat
A cross sectional study was conducted on 2231 small ruminants in four districts of the Afar Pastoral Region of Ethiopia to investigate the epidemiology of tuberculosis in goats and sheep using comparative intradermal tuberculin skin test, postmortem examination, mycobacteriological culture and mole...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2012/869146 |
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| author | Gezahegne Mamo Kassa Fekadu Abebe Yalelet Worku Mengistu Legesse Girmay Medhin Gunnar Bjune Gobena Ameni |
| author_facet | Gezahegne Mamo Kassa Fekadu Abebe Yalelet Worku Mengistu Legesse Girmay Medhin Gunnar Bjune Gobena Ameni |
| author_sort | Gezahegne Mamo Kassa |
| collection | DOAJ |
| description | A cross sectional study was conducted on 2231 small ruminants in four districts of the Afar Pastoral Region of Ethiopia to investigate the
epidemiology of tuberculosis in goats and sheep using comparative intradermal tuberculin skin test, postmortem examination, mycobacteriological culture and molecular typing methods. The overall animal prevalence of TB in small ruminants was 0.5% (95% CI: 0.2%–0.7%) at ≥4 mm and 3.8% (95% CI: 3%–4.7%) at cutoff ≥2 mm. The herd prevalence was 20% (95% CI: 12–28%) and 47% (95% CI: 37–56%) at ≥4 mm and ≥2 mm cut-off points, respectively. The overall animal prevalence of Mycobacterium avium complex infection was 2.8% (95% CI: 2.1–3.5%) and 6.8% (95% CI: 5.8–7.9%) at ≥4 mm and ≥2 mm cut-off points, respectively. Mycobacteriological culture and molecular characterization of isolates from tissue lesions of tuberculin reactor goats resulted in isolation of Mycobacterium tuberculosis (SIT149) and non-tuberculosis mycobacteria as causative agents of tuberculosis and tuberculosis-like diseases in goats, respectively. The isolation of Mycobacterium tuberculosis in goat suggests a potential transmission of the causative agent from human and warrants further investigation in the role of small ruminants in epidemiology of human tuberculosis in the region. |
| format | Article |
| id | doaj-art-250c9fc411d14f7f937fb7ddff04fc8c |
| institution | Kabale University |
| issn | 2090-8113 2042-0048 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-250c9fc411d14f7f937fb7ddff04fc8c2025-08-20T03:54:52ZengWileyVeterinary Medicine International2090-81132042-00482012-01-01201210.1155/2012/869146869146Tuberculosis in Goats and Sheep in Afar Pastoral Region of Ethiopia and Isolation of Mycobacterium tuberculosis from GoatGezahegne Mamo Kassa0Fekadu Abebe1Yalelet Worku2Mengistu Legesse3Girmay Medhin4Gunnar Bjune5Gobena Ameni6Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, EthiopiaFaculty of Medicine, Institute of Health and Society, Department of Community Medicine, International Community Health, University of Oslo, P.O. Box 1130, Blindern N-0318 Oslo, NorwayFaculty of Veterinary Medicine, Addis Ababa University, P.O. Box 34, Debre Zeit, EthiopiaAklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, EthiopiaAklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, EthiopiaFaculty of Medicine, Institute of Health and Society, Department of Community Medicine, International Community Health, University of Oslo, P.O. Box 1130, Blindern N-0318 Oslo, NorwayAklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, EthiopiaA cross sectional study was conducted on 2231 small ruminants in four districts of the Afar Pastoral Region of Ethiopia to investigate the epidemiology of tuberculosis in goats and sheep using comparative intradermal tuberculin skin test, postmortem examination, mycobacteriological culture and molecular typing methods. The overall animal prevalence of TB in small ruminants was 0.5% (95% CI: 0.2%–0.7%) at ≥4 mm and 3.8% (95% CI: 3%–4.7%) at cutoff ≥2 mm. The herd prevalence was 20% (95% CI: 12–28%) and 47% (95% CI: 37–56%) at ≥4 mm and ≥2 mm cut-off points, respectively. The overall animal prevalence of Mycobacterium avium complex infection was 2.8% (95% CI: 2.1–3.5%) and 6.8% (95% CI: 5.8–7.9%) at ≥4 mm and ≥2 mm cut-off points, respectively. Mycobacteriological culture and molecular characterization of isolates from tissue lesions of tuberculin reactor goats resulted in isolation of Mycobacterium tuberculosis (SIT149) and non-tuberculosis mycobacteria as causative agents of tuberculosis and tuberculosis-like diseases in goats, respectively. The isolation of Mycobacterium tuberculosis in goat suggests a potential transmission of the causative agent from human and warrants further investigation in the role of small ruminants in epidemiology of human tuberculosis in the region.http://dx.doi.org/10.1155/2012/869146 |
| spellingShingle | Gezahegne Mamo Kassa Fekadu Abebe Yalelet Worku Mengistu Legesse Girmay Medhin Gunnar Bjune Gobena Ameni Tuberculosis in Goats and Sheep in Afar Pastoral Region of Ethiopia and Isolation of Mycobacterium tuberculosis from Goat Veterinary Medicine International |
| title | Tuberculosis in Goats and Sheep in Afar Pastoral Region of Ethiopia and Isolation of Mycobacterium tuberculosis from Goat |
| title_full | Tuberculosis in Goats and Sheep in Afar Pastoral Region of Ethiopia and Isolation of Mycobacterium tuberculosis from Goat |
| title_fullStr | Tuberculosis in Goats and Sheep in Afar Pastoral Region of Ethiopia and Isolation of Mycobacterium tuberculosis from Goat |
| title_full_unstemmed | Tuberculosis in Goats and Sheep in Afar Pastoral Region of Ethiopia and Isolation of Mycobacterium tuberculosis from Goat |
| title_short | Tuberculosis in Goats and Sheep in Afar Pastoral Region of Ethiopia and Isolation of Mycobacterium tuberculosis from Goat |
| title_sort | tuberculosis in goats and sheep in afar pastoral region of ethiopia and isolation of mycobacterium tuberculosis from goat |
| url | http://dx.doi.org/10.1155/2012/869146 |
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