Nanocatalytic medicine enabled next-generation therapeutics for bacterial infections
The rapid rise of antibiotic-resistant strains and the persistence of biofilm-associated infections have significantly challenged global public health. Unfortunately, current clinical high-dose antibiotic regimens and combination therapies often fail to completely eradicate these infections, which c...
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Elsevier
2024-12-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424003168 |
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| author | Min Ge Feng Jiang Han Lin |
| author_facet | Min Ge Feng Jiang Han Lin |
| author_sort | Min Ge |
| collection | DOAJ |
| description | The rapid rise of antibiotic-resistant strains and the persistence of biofilm-associated infections have significantly challenged global public health. Unfortunately, current clinical high-dose antibiotic regimens and combination therapies often fail to completely eradicate these infections, which can lead to adverse side effects and further drug resistance. Amidst this challenge, however, the burgeoning development in nanotechnology and nanomaterials brings hopes. This review provides a comprehensive summary of recent advancements in nanomaterials for treating bacterial infections. Firstly, the research progress of catalytic therapies in the field of antimicrobials is comprehensively discussed. Thereafter, we systematically discuss the strategies of nanomaterials for anti-bacterial infection therapies, including endogenous response catalytic therapy, exogenous stimulation catalytic therapy, and catalytic immunotherapy, in order to elucidate the mechanism of nanocatalytic anti-infections. Based on the current state of the art, we conclude with insights on the remaining challenges and future prospects in this rapidly emerging field. |
| format | Article |
| id | doaj-art-2502ee20d7e04ddb9be0e43a72a8c5c2 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-2502ee20d7e04ddb9be0e43a72a8c5c22024-12-14T06:32:00ZengElsevierMaterials Today Bio2590-00642024-12-0129101255Nanocatalytic medicine enabled next-generation therapeutics for bacterial infectionsMin Ge0Feng Jiang1Han Lin2Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, ChinaDepartment of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, 200233, China; Corresponding author.Shanghai Institute of Ceramics Chinese Academy of Sciences, Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Chinese Academy of Medical Sciences, Shanghai, 200050, China; Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, Shanghai, 200331, China; Corresponding author. Shanghai Institute of Ceramics Chinese Academy of Sciences, Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Chinese Academy of Medical Sciences, Shanghai, 200050, China.The rapid rise of antibiotic-resistant strains and the persistence of biofilm-associated infections have significantly challenged global public health. Unfortunately, current clinical high-dose antibiotic regimens and combination therapies often fail to completely eradicate these infections, which can lead to adverse side effects and further drug resistance. Amidst this challenge, however, the burgeoning development in nanotechnology and nanomaterials brings hopes. This review provides a comprehensive summary of recent advancements in nanomaterials for treating bacterial infections. Firstly, the research progress of catalytic therapies in the field of antimicrobials is comprehensively discussed. Thereafter, we systematically discuss the strategies of nanomaterials for anti-bacterial infection therapies, including endogenous response catalytic therapy, exogenous stimulation catalytic therapy, and catalytic immunotherapy, in order to elucidate the mechanism of nanocatalytic anti-infections. Based on the current state of the art, we conclude with insights on the remaining challenges and future prospects in this rapidly emerging field.http://www.sciencedirect.com/science/article/pii/S2590006424003168Nano-catalysisAntibacterialReactive oxygen speciesBiomedicine |
| spellingShingle | Min Ge Feng Jiang Han Lin Nanocatalytic medicine enabled next-generation therapeutics for bacterial infections Materials Today Bio Nano-catalysis Antibacterial Reactive oxygen species Biomedicine |
| title | Nanocatalytic medicine enabled next-generation therapeutics for bacterial infections |
| title_full | Nanocatalytic medicine enabled next-generation therapeutics for bacterial infections |
| title_fullStr | Nanocatalytic medicine enabled next-generation therapeutics for bacterial infections |
| title_full_unstemmed | Nanocatalytic medicine enabled next-generation therapeutics for bacterial infections |
| title_short | Nanocatalytic medicine enabled next-generation therapeutics for bacterial infections |
| title_sort | nanocatalytic medicine enabled next generation therapeutics for bacterial infections |
| topic | Nano-catalysis Antibacterial Reactive oxygen species Biomedicine |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424003168 |
| work_keys_str_mv | AT minge nanocatalyticmedicineenablednextgenerationtherapeuticsforbacterialinfections AT fengjiang nanocatalyticmedicineenablednextgenerationtherapeuticsforbacterialinfections AT hanlin nanocatalyticmedicineenablednextgenerationtherapeuticsforbacterialinfections |