The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review
Objective To critically analyse literature on the anticancer properties of andrographolide in in vitro studies on gastric cancer cells. Method This study systematically reviewed articles from 2013 to 2024 across five prominent databases; PubMed, Google Scholar, Web of Science, Scopus, and Science Di...
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PeerJ Inc.
2024-11-01
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| author | Muhamad Alojid Anis Amiera Tuan Noorkorina Tuan Kub Azian Harun Rohimah Mohamud Nur Rina Alissa Razian Yasmin Khairani Muhammad Ismadi Wan Alif Syazwani Wan Alias Mohammed Hussain Abdulrazak Ernawati Teni |
| author_facet | Muhamad Alojid Anis Amiera Tuan Noorkorina Tuan Kub Azian Harun Rohimah Mohamud Nur Rina Alissa Razian Yasmin Khairani Muhammad Ismadi Wan Alif Syazwani Wan Alias Mohammed Hussain Abdulrazak Ernawati Teni |
| author_sort | Muhamad Alojid Anis Amiera |
| collection | DOAJ |
| description | Objective To critically analyse literature on the anticancer properties of andrographolide in in vitro studies on gastric cancer cells. Method This study systematically reviewed articles from 2013 to 2024 across five prominent databases; PubMed, Google Scholar, Web of Science, Scopus, and Science Direct, EMBASE, Cochrane library and DOAJ. The study eligibility criteria include original studies assessing using gastric cancer cell lines and articles utilizing extracted andrographolide from Andrographis paniculata or standard andrographolide source treatment. The following exclusion criteria were articles written in a different language, review articles, book chapters, conference articles, scientific reports. Duplicated articles were removed using Mendeley software. Result Out of 93 articles, six were relevant, primarily focusing on in vitro analyses with gastric adenocarcinoma cell lines. Conclusion These studies indicate that andrographolide can hinder the cell cycle, suppress cell proliferation, alleviate oxidative stress, and induce apoptosis by prompting gastric cancer cells to undergo self-destruction, which is a crucial mechanism for controlling and eliminating cancerous growths. |
| format | Article |
| id | doaj-art-24d1fa2c48024c8b86a849234cf3dc33 |
| institution | Kabale University |
| issn | 2167-8359 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj-art-24d1fa2c48024c8b86a849234cf3dc332024-11-22T15:05:18ZengPeerJ Inc.PeerJ2167-83592024-11-0112e1851310.7717/peerj.18513The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic reviewMuhamad Alojid Anis Amiera0Tuan Noorkorina Tuan Kub1Azian Harun2Rohimah Mohamud3Nur Rina Alissa Razian4Yasmin Khairani Muhammad Ismadi5Wan Alif Syazwani Wan Alias6Mohammed Hussain Abdulrazak7Ernawati Teni8Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, MalaysiaDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, MalaysiaDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, MalaysiaDepartment of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, MalaysiaDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, MalaysiaDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, MalaysiaDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, MalaysiaDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, MalaysiaNational Research and Innovation Agency (BRIN), Research Centre for Pharmaceutical Ingredients and Traditional Medicines, Yogjakarta, IndonesiaObjective To critically analyse literature on the anticancer properties of andrographolide in in vitro studies on gastric cancer cells. Method This study systematically reviewed articles from 2013 to 2024 across five prominent databases; PubMed, Google Scholar, Web of Science, Scopus, and Science Direct, EMBASE, Cochrane library and DOAJ. The study eligibility criteria include original studies assessing using gastric cancer cell lines and articles utilizing extracted andrographolide from Andrographis paniculata or standard andrographolide source treatment. The following exclusion criteria were articles written in a different language, review articles, book chapters, conference articles, scientific reports. Duplicated articles were removed using Mendeley software. Result Out of 93 articles, six were relevant, primarily focusing on in vitro analyses with gastric adenocarcinoma cell lines. Conclusion These studies indicate that andrographolide can hinder the cell cycle, suppress cell proliferation, alleviate oxidative stress, and induce apoptosis by prompting gastric cancer cells to undergo self-destruction, which is a crucial mechanism for controlling and eliminating cancerous growths.https://peerj.com/articles/18513.pdfAndrographis paniculataAndrographolideIn vitroGastric cancer cell linesAnticancer |
| spellingShingle | Muhamad Alojid Anis Amiera Tuan Noorkorina Tuan Kub Azian Harun Rohimah Mohamud Nur Rina Alissa Razian Yasmin Khairani Muhammad Ismadi Wan Alif Syazwani Wan Alias Mohammed Hussain Abdulrazak Ernawati Teni The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review PeerJ Andrographis paniculata Andrographolide In vitro Gastric cancer cell lines Anticancer |
| title | The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review |
| title_full | The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review |
| title_fullStr | The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review |
| title_full_unstemmed | The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review |
| title_short | The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review |
| title_sort | role of andrographolide as a potential anticancer agent against gastric cancer cell lines a systematic review |
| topic | Andrographis paniculata Andrographolide In vitro Gastric cancer cell lines Anticancer |
| url | https://peerj.com/articles/18513.pdf |
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