A prospective, multicenter analysis of the integrated 31-gene expression profile test for sentinel lymph node biopsy (i31-GEP for SLNB) test demonstrates reduced number of unnecessary SLNBs in patients with cutaneous melanoma

A prospective, multicenter analysis of the integrated 31-gene expression profile test for sentinel lymph node biopsy (i31-GEP for SLNB) test demonstrates reduced number of unnecessary SLNBs in patients with cutaneous melanoma

Abstract Background National Comprehensive Cancer Network guidelines recommend sentinel lymph node biopsy (SLNB) for patients with > 10% risk of positivity, consider SLNB with 5–10% risk, and foregoing with < 5% risk. The integrated 31-gene expression profile (i31-GEP) algorithm combines the 3...

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Bibliographic Details
Main Authors: J. Michael Guenther, Andrew Ward, Brian J. Martin, Mark Cripe, Rohit Sharma, Stanley P. Leong, Joseph I. Clark, John Hamner, Timothy Beard
Format: Article
Language:English
Published: BMC 2025-01-01
Series:World Journal of Surgical Oncology
Subjects:
Cutaneous melanoma
Gene expression profiling
31-GEP
Sentinel lymph node biopsy
Prognosis
Online Access:https://doi.org/10.1186/s12957-024-03640-x
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