Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system
Background: Leptin is an adipose tissue-derived hormone that plays a crucial role in body weight, appetite, and behaviour regulation. Leptin controls energy balance as an indicator of adiposity levels and as a modulator of the reward system, which is associated with liking palatable foods. Obesity i...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Molecular Metabolism |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212877824002096 |
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| author | Roshanak Asgari Maria Caceres-Valdiviezo Sally Wu Laurie Hamel Bailey E. Humber Sri Mahavir Agarwal Paul J. Fletcher Stephanie Fulton Margaret K. Hahn Sandra Pereira |
| author_facet | Roshanak Asgari Maria Caceres-Valdiviezo Sally Wu Laurie Hamel Bailey E. Humber Sri Mahavir Agarwal Paul J. Fletcher Stephanie Fulton Margaret K. Hahn Sandra Pereira |
| author_sort | Roshanak Asgari |
| collection | DOAJ |
| description | Background: Leptin is an adipose tissue-derived hormone that plays a crucial role in body weight, appetite, and behaviour regulation. Leptin controls energy balance as an indicator of adiposity levels and as a modulator of the reward system, which is associated with liking palatable foods. Obesity is characterized by expanded adipose tissue mass and consequently, elevated concentrations of leptin in blood. Leptin's therapeutic potential for most forms of obesity is hampered by leptin resistance and a narrow dose–response window. Scope of Review: This review describes the current knowledge of the brain regions and intracellular pathways through which leptin promotes negative energy balance and restrains neural circuits affecting food reward. We also describe mechanisms that hinder these biological responses in obesity and highlight potential therapeutic interventions. Major Conclusions: Additional research is necessary to understand how pathways engaged by leptin in different brain regions are interconnected in the control of energy balance. |
| format | Article |
| id | doaj-art-24c6aabc33bf4b5ba718f0ad06957f15 |
| institution | Kabale University |
| issn | 2212-8778 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Metabolism |
| spelling | doaj-art-24c6aabc33bf4b5ba718f0ad06957f152025-01-09T06:13:55ZengElsevierMolecular Metabolism2212-87782025-01-0191102078Regulation of energy balance by leptin as an adiposity signal and modulator of the reward systemRoshanak Asgari0Maria Caceres-Valdiviezo1Sally Wu2Laurie Hamel3Bailey E. Humber4Sri Mahavir Agarwal5Paul J. Fletcher6Stephanie Fulton7Margaret K. Hahn8Sandra Pereira9Centre for Addiction and Mental Health, Toronto, ON, CanadaCentre for Addiction and Mental Health, Toronto, ON, Canada; Laboratory of Omic Sciences, School of Medicine, Universidad de Especialidades Espíritu Santo, Samborondón, EcuadorCentre for Addiction and Mental Health, Toronto, ON, CanadaCentre for Addiction and Mental Health, Toronto, ON, CanadaCentre for Addiction and Mental Health, Toronto, ON, CanadaCentre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Banting & Best Diabetes Centre, University of Toronto, Toronto, ON, CanadaCentre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Psychology, University of Toronto, Toronto, ON, CanadaCentre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal Diabetes Research Center, Montréal, QC, Canada; Department of Nutrition, Université de Montréal, QC, CanadaCentre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Banting & Best Diabetes Centre, University of Toronto, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Corresponding author. Centre for Addiction and Mental Health, 1051 Queen St- 2405, Toronto, ON, M6J 1H3, Canada.Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Corresponding author. 250 College Street, Room 360 Toronto, ON M5T 1R8 Canada.Background: Leptin is an adipose tissue-derived hormone that plays a crucial role in body weight, appetite, and behaviour regulation. Leptin controls energy balance as an indicator of adiposity levels and as a modulator of the reward system, which is associated with liking palatable foods. Obesity is characterized by expanded adipose tissue mass and consequently, elevated concentrations of leptin in blood. Leptin's therapeutic potential for most forms of obesity is hampered by leptin resistance and a narrow dose–response window. Scope of Review: This review describes the current knowledge of the brain regions and intracellular pathways through which leptin promotes negative energy balance and restrains neural circuits affecting food reward. We also describe mechanisms that hinder these biological responses in obesity and highlight potential therapeutic interventions. Major Conclusions: Additional research is necessary to understand how pathways engaged by leptin in different brain regions are interconnected in the control of energy balance.http://www.sciencedirect.com/science/article/pii/S2212877824002096LeptinBody weightFood intakeReward system |
| spellingShingle | Roshanak Asgari Maria Caceres-Valdiviezo Sally Wu Laurie Hamel Bailey E. Humber Sri Mahavir Agarwal Paul J. Fletcher Stephanie Fulton Margaret K. Hahn Sandra Pereira Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system Molecular Metabolism Leptin Body weight Food intake Reward system |
| title | Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system |
| title_full | Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system |
| title_fullStr | Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system |
| title_full_unstemmed | Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system |
| title_short | Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system |
| title_sort | regulation of energy balance by leptin as an adiposity signal and modulator of the reward system |
| topic | Leptin Body weight Food intake Reward system |
| url | http://www.sciencedirect.com/science/article/pii/S2212877824002096 |
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