Perceptual learning and neural correlates of virtual navigation in subjective cognitive decline: A pilot study
Summary: Spatial navigation deficits in age-related diseases involve brain changes affecting spatial memory and verbal cognition. Studies in blind and blindfolded individuals show that multisensory training can induce neuroplasticity through visual cortex recruitment. This proof-of-concept study int...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224026361 |
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| author | Amir Amedi Shahar Shelly Nira Saporta Merav Catalogna |
| author_facet | Amir Amedi Shahar Shelly Nira Saporta Merav Catalogna |
| author_sort | Amir Amedi |
| collection | DOAJ |
| description | Summary: Spatial navigation deficits in age-related diseases involve brain changes affecting spatial memory and verbal cognition. Studies in blind and blindfolded individuals show that multisensory training can induce neuroplasticity through visual cortex recruitment. This proof-of-concept study introduces a digital navigation training protocol, integrating egocentric and allocentric strategies with multisensory stimulation and visual masking to enhance spatial cognition and brain connectivity in 17 individuals (mean age 57.2 years) with subjective cognitive decline. Results indicate improved spatial memory performance correlated with recruitment of the visual area 6-thalamic pathway and enhanced connectivity between memory, executive frontal areas, and default mode network (DMN) regions. Additionally, increased connectivity between allocentric and egocentric navigation areas via the retrosplenial complex (RSC) hub was observed. These findings suggest that this training has the potential to induce perceptual learning and neuroplasticity through key functional connectivity hubs, offering potential widespread cognitive benefits by enhancing critical brain network functions. |
| format | Article |
| id | doaj-art-24aeed601fc34b3da7806c7a816a9fe9 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-24aeed601fc34b3da7806c7a816a9fe92024-12-22T05:29:16ZengElsevieriScience2589-00422024-12-012712111411Perceptual learning and neural correlates of virtual navigation in subjective cognitive decline: A pilot studyAmir Amedi0Shahar Shelly1Nira Saporta2Merav Catalogna3The Baruch Ivcher Institute for Brain, Cognition, and Technology, Baruch Ivcher School of Psychology, Reichman University, Herzliya, Israel; Corresponding authorDepartment of Neurology, Rambam Medical Center, Haifa, Israel; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, IsraelRemepy Health Ltd, Ramat Gan, IsraelThe Baruch Ivcher Institute for Brain, Cognition, and Technology, Baruch Ivcher School of Psychology, Reichman University, Herzliya, Israel; Corresponding authorSummary: Spatial navigation deficits in age-related diseases involve brain changes affecting spatial memory and verbal cognition. Studies in blind and blindfolded individuals show that multisensory training can induce neuroplasticity through visual cortex recruitment. This proof-of-concept study introduces a digital navigation training protocol, integrating egocentric and allocentric strategies with multisensory stimulation and visual masking to enhance spatial cognition and brain connectivity in 17 individuals (mean age 57.2 years) with subjective cognitive decline. Results indicate improved spatial memory performance correlated with recruitment of the visual area 6-thalamic pathway and enhanced connectivity between memory, executive frontal areas, and default mode network (DMN) regions. Additionally, increased connectivity between allocentric and egocentric navigation areas via the retrosplenial complex (RSC) hub was observed. These findings suggest that this training has the potential to induce perceptual learning and neuroplasticity through key functional connectivity hubs, offering potential widespread cognitive benefits by enhancing critical brain network functions.http://www.sciencedirect.com/science/article/pii/S2589004224026361NeuroscienceCognitive neuroscience |
| spellingShingle | Amir Amedi Shahar Shelly Nira Saporta Merav Catalogna Perceptual learning and neural correlates of virtual navigation in subjective cognitive decline: A pilot study iScience Neuroscience Cognitive neuroscience |
| title | Perceptual learning and neural correlates of virtual navigation in subjective cognitive decline: A pilot study |
| title_full | Perceptual learning and neural correlates of virtual navigation in subjective cognitive decline: A pilot study |
| title_fullStr | Perceptual learning and neural correlates of virtual navigation in subjective cognitive decline: A pilot study |
| title_full_unstemmed | Perceptual learning and neural correlates of virtual navigation in subjective cognitive decline: A pilot study |
| title_short | Perceptual learning and neural correlates of virtual navigation in subjective cognitive decline: A pilot study |
| title_sort | perceptual learning and neural correlates of virtual navigation in subjective cognitive decline a pilot study |
| topic | Neuroscience Cognitive neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224026361 |
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