A Case Series of Diagnostic Challenges in Mycosis Fungoides in Resource-poor Settings: Blood Film Examination – A Useful Tool
The prognosis/mortality rate in mycosis fungoides (MF)/cutaneous T-cell lymphomas (CTCL) is alarming in resource-poor countries due to delayed diagnosis in meeting recognised criteria. We highlight the diagnostic accuracy of examining peripheral blood films (PBFs). We reviewed clinically diagnosed M...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Nigerian Postgraduate Medical Journal |
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| Online Access: | https://journals.lww.com/10.4103/npmj.npmj_48_24 |
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| author | Erere Otrofanowei Ayesha Omolara Akinkugbe Yusuf Adetomiwa Adelabu Olusola Olabisi Ayanlowo |
| author_facet | Erere Otrofanowei Ayesha Omolara Akinkugbe Yusuf Adetomiwa Adelabu Olusola Olabisi Ayanlowo |
| author_sort | Erere Otrofanowei |
| collection | DOAJ |
| description | The prognosis/mortality rate in mycosis fungoides (MF)/cutaneous T-cell lymphomas (CTCL) is alarming in resource-poor countries due to delayed diagnosis in meeting recognised criteria. We highlight the diagnostic accuracy of examining peripheral blood films (PBFs). We reviewed clinically diagnosed MF/CTCL cases in the Dermatology Clinic of Lagos University Teaching Hospital between January and October 2022 and analysed clinical, haematological and histology findings. Eight patients (male:female = 5:3) between 35 and 68 years had blood films with characteristic Sezary cells of <5%. Flow cytometry (FC) in 1 (12.5%) was inconclusive, and immunohistochemistry (IHC) on skin/lymph nodes in 5 (62.5%) was highly suggestive or confirmatory. Three patients had no biopsy. Patients had methotrexate, phototherapy (±psoralen) and systemic steroids with varying improvements. Since immunophenotyping (FC or IHC) is lacking in resource-poor countries or low- and middle-income countries, Sezary cells in PBF of clinically diagnosed patients with MF/CTCL should prompt treatment. |
| format | Article |
| id | doaj-art-249762cefe624685b701e468fb071872 |
| institution | Kabale University |
| issn | 1117-1936 2468-6875 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Nigerian Postgraduate Medical Journal |
| spelling | doaj-art-249762cefe624685b701e468fb0718722025-01-07T09:47:56ZengWolters Kluwer Medknow PublicationsNigerian Postgraduate Medical Journal1117-19362468-68752024-12-0131433734010.4103/npmj.npmj_48_24A Case Series of Diagnostic Challenges in Mycosis Fungoides in Resource-poor Settings: Blood Film Examination – A Useful ToolErere OtrofanoweiAyesha Omolara AkinkugbeYusuf Adetomiwa AdelabuOlusola Olabisi AyanlowoThe prognosis/mortality rate in mycosis fungoides (MF)/cutaneous T-cell lymphomas (CTCL) is alarming in resource-poor countries due to delayed diagnosis in meeting recognised criteria. We highlight the diagnostic accuracy of examining peripheral blood films (PBFs). We reviewed clinically diagnosed MF/CTCL cases in the Dermatology Clinic of Lagos University Teaching Hospital between January and October 2022 and analysed clinical, haematological and histology findings. Eight patients (male:female = 5:3) between 35 and 68 years had blood films with characteristic Sezary cells of <5%. Flow cytometry (FC) in 1 (12.5%) was inconclusive, and immunohistochemistry (IHC) on skin/lymph nodes in 5 (62.5%) was highly suggestive or confirmatory. Three patients had no biopsy. Patients had methotrexate, phototherapy (±psoralen) and systemic steroids with varying improvements. Since immunophenotyping (FC or IHC) is lacking in resource-poor countries or low- and middle-income countries, Sezary cells in PBF of clinically diagnosed patients with MF/CTCL should prompt treatment.https://journals.lww.com/10.4103/npmj.npmj_48_24blood filmcutaneous t-cell lymphomamycosis fungoidesresource-poor countriessezary cells |
| spellingShingle | Erere Otrofanowei Ayesha Omolara Akinkugbe Yusuf Adetomiwa Adelabu Olusola Olabisi Ayanlowo A Case Series of Diagnostic Challenges in Mycosis Fungoides in Resource-poor Settings: Blood Film Examination – A Useful Tool Nigerian Postgraduate Medical Journal blood film cutaneous t-cell lymphoma mycosis fungoides resource-poor countries sezary cells |
| title | A Case Series of Diagnostic Challenges in Mycosis Fungoides in Resource-poor Settings: Blood Film Examination – A Useful Tool |
| title_full | A Case Series of Diagnostic Challenges in Mycosis Fungoides in Resource-poor Settings: Blood Film Examination – A Useful Tool |
| title_fullStr | A Case Series of Diagnostic Challenges in Mycosis Fungoides in Resource-poor Settings: Blood Film Examination – A Useful Tool |
| title_full_unstemmed | A Case Series of Diagnostic Challenges in Mycosis Fungoides in Resource-poor Settings: Blood Film Examination – A Useful Tool |
| title_short | A Case Series of Diagnostic Challenges in Mycosis Fungoides in Resource-poor Settings: Blood Film Examination – A Useful Tool |
| title_sort | case series of diagnostic challenges in mycosis fungoides in resource poor settings blood film examination a useful tool |
| topic | blood film cutaneous t-cell lymphoma mycosis fungoides resource-poor countries sezary cells |
| url | https://journals.lww.com/10.4103/npmj.npmj_48_24 |
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