Cancer-associated fibroblasts in carcinogenesis

Cancer-associated fibroblasts in carcinogenesis

Abstract In contemporary times, cancer poses the most significant threat to human life and safety. Scientists have relentlessly pursued the intricacies of carcinogenesis and explored ways to prevent and treat cancer. Carcinogenesis is a complex, multi-faceted, and multi-stage process, with numerous...

Full description

Saved in:

Bibliographic Details
Main Authors:	Shufen Zhou, Zekun Zhao, Zhaojun Wang, Hanzheng Xu, Yijie Li, Ke Xu, Wei Li, Jiahua Yang
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Series:	Journal of Translational Medicine
Subjects:	Cancer-associated fibroblasts Carcinogenesis Breast cancer Colorectal cancer
Online Access:	https://doi.org/10.1186/s12967-025-06071-8
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts
by: Zhongsong Zhang, et al.
Published: (2025-01-01)

Cancer-associated fibroblasts induce almonertinib resistance in non-small cell lung cancer
by: Guohao Wei, et al.
Published: (2025-01-01)

PDPN+ cancer‐associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF‐κB activation and the CCL2‐ACKR1 axis
by: Zhenxiong Zhao, et al.
Published: (2025-01-01)

Cancer-associated fibroblasts and their role in tumor progression
by: M. S. Ermakov, et al.
Published: (2022-03-01)

Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy
by: Zhang Z, et al.
Published: (2025-01-01)

Heterogeneity of cancer-associated fibroblast subpopulations in prostate cancer: Implications for prognosis and immunotherapy
by: Chen Ding, et al.
Published: (2025-02-01)

E2F1 activates breast stromal fibroblasts and promotes their paracrine pro-carcinogenic effects
by: Layla A. Al-Kharashi, et al.
Published: (2025-02-01)

Bilayer 3D co‐culture platform inducing the differentiation of normal fibroblasts into cancer‐associated fibroblast like cells: New in vitro source to obtain cancer‐associated fibroblasts
by: Yeon Ju Kim, et al.
Published: (2025-01-01)

Cancer-associated fibroblasts promote pro-tumor functions of neutrophils in pancreatic cancer via IL-8: potential suppression by pirfenidone
by: Tomohiko Yagi, et al.
Published: (2025-02-01)

Novel treatment strategy targeting interleukin-6 induced by cancer associated fibroblasts for peritoneal metastasis of gastric cancer
by: Ema Mitsui, et al.
Published: (2025-01-01)

Evaluation of the significance of tumor stromal patterns and peri-tumoral inflammation in head and neck squamous cell carcinoma with special reference to the Yamamoto–Kohama classification
by: Geet Bhuyan, et al.
Published: (2024-04-01)

Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects
by: Zhipeng Cao, et al.
Published: (2025-01-01)

S100A13-driven interaction between pancreatic adenocarcinoma cells and cancer-associated fibroblasts promotes tumor progression through calcium signaling
by: Liuyuan Xia, et al.
Published: (2025-01-01)

Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts through regulation of the HOXA6/ZBTB12 axis
by: Liu Haibo, et al.
Published: (2023-09-01)

Bisecting GlcNAc modification of vesicular GAS6 regulates CAFs activation and breast cancer metastasis
by: Jing Li, et al.
Published: (2025-01-01)

The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration
by: Chiara Cencioni, et al.
Published: (2025-01-01)

Deciphering the heterogeneity and plasticity of the tumor microenvironment in liver cancer provides insights for prognosis
by: Yihao Sun, et al.
Published: (2025-01-01)

Spatial profiling of endoplasmic reticulum stress markers in tumor associated cells predicts patient outcomes in pancreatic cancer
by: Georgia Porter, et al.
Published: (2025-02-01)

Dysbiosis and extraintestinal cancers
by: Ruishan He, et al.
Published: (2025-02-01)

Human microbiomes in cancer development and therapy
by: Chenglai Xia, et al.
Published: (2023-04-01)

Rise in arsenic pollution and oral cancer: A call for action
by: Amol S. Dhane, et al.
Published: (2024-03-01)

Solid Predominant Histology and High Podoplanin Expression in Cancer-Associated Fibroblast Predict Primary Resistance to Osimertinib in EGFR-Mutated Lung Adenocarcinoma
by: Yuji Uehara, MD, et al.
Published: (2025-03-01)

Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment
by: Nuo Cheng, et al.
Published: (2025-02-01)

Giant triple negative pregnancy-associated breast cancer (PABC) in a young woman: From diagnosis to therapy step by step: A case report
by: Micol Bottalico, et al.
Published: (2025-03-01)

Desmoglein-2 was a novel cancer-associated fibroblasts-related biomarker for oral squamous cell carcinoma
by: Jin Liu, et al.
Published: (2025-01-01)

The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression
by: Yige Zhao, et al.
Published: (2025-02-01)

Quality of life for patients on oncology treatments in the Kingdom of Saudi Arabia: a systematic review
by: Abdullah U. Althemery, et al.
Published: (2025-12-01)

Engineered CAF-cancer cell hybrid membrane biomimetic dual-targeted integrated platform for multi-dimensional treatment of ovarian cancer
by: Yuwei Yao, et al.
Published: (2025-02-01)

Identification and validation of a metabolic-related gene risk model predicting the prognosis of lung, colon, and breast cancers
by: Jiyauddin Khan, et al.
Published: (2025-01-01)

Organoid models: applications and research advances in colorectal cancer
by: Yijie Wu, et al.
Published: (2025-02-01)

Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization
by: Lu Ding, et al.
Published: (2025-02-01)

Integrated analysis of cell cycle and p53 signaling pathways related genes in breast, colorectal, lung, and pancreatic cancers: implications for prognosis and drug sensitivity for therapeutic potential
by: Jiyauddin Khan, et al.
Published: (2024-12-01)

LAMB1 promotes proliferation and metastasis in nasopharyngeal carcinoma and shapes the immune-suppressive tumor microenvironment
by: Enzi Feng, et al.
Published: (2025-03-01)

Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients
by: Stella Maris Ranuncolo, et al.
Published: (2025-01-01)

Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment
by: Wu S, et al.
Published: (2025-02-01)

Implication of fibroblast growth factor 7 in ovarian cancer metastases and patient survival
by: Laura F. Mortan, et al.
Published: (2025-01-01)

Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences
by: Pål Møller, et al.
Published: (2025-01-01)

A novel interplay between bacteria and metabolites in different early-stage lung cancer: an integrated microbiome and metabolome analysis
by: Xiaoqian Zhai, et al.
Published: (2025-01-01)

Association of dietary intake with cancer of the digestive system: a cross-sectional study
by: Xinxin Qin, et al.
Published: (2025-01-01)

Meta-Analysis and Systematic Review of the Role of Appendectomy in the Pathogenesis of Colorectal Cancer
by: M.I. A. Nezhad, et al.
Published: (2024-05-01)