The relationship between metformin administration and age-related macular degeneration; a systematic review and meta-analysis of observational studies
Introduction: Vision loss due to age-related macular degeneration (AMD) is a major and growing health issue. Given that no definitive treatment is available for AMD, this study aims to evaluate the association between metformin use and AMD risk using a systematic review and meta-analysis approach. M...
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| Format: | Article |
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Society of Diabetic Nephropathy Prevention
2024-06-01
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| Series: | Journal of Nephropharmacology |
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| Online Access: | https://jnephropharmacology.com/PDF/npj-13-e12690.pdf |
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| author | Abdulateef Abdulkadhium mashaf Mohammed Abdul-Mounther Othman Omer Mansib Kassid Hakim S. Sultan Aljibori Abdul Amir H kadhum Ahmed Ali Mohammed Raed Muslim Mhaibes |
| author_facet | Abdulateef Abdulkadhium mashaf Mohammed Abdul-Mounther Othman Omer Mansib Kassid Hakim S. Sultan Aljibori Abdul Amir H kadhum Ahmed Ali Mohammed Raed Muslim Mhaibes |
| author_sort | Abdulateef Abdulkadhium mashaf |
| collection | DOAJ |
| description | Introduction: Vision loss due to age-related macular degeneration (AMD) is a major and growing health issue. Given that no definitive treatment is available for AMD, this study aims to evaluate the association between metformin use and AMD risk using a systematic review and meta-analysis approach. Materials and Methods: In this study, databases including ProQuest, PubMed, Web of Science, Cochrane, and Google Scholar search engines were searched without time restriction until April 20, 2024, based on PRISMA statement guidelines. Data were analyzed using STATA 14 software at a significance level of P < 0.05. Results: Overall, metformin administration reduced the risk of AMD (OR: 0.86, 95% CI: 0.80, 0.94). Concerning the dosage, a metformin dose of 1-270 g per 2 years (OR: 0.93, 95% CI: 0.90, 0.96) and 271-600 g per 2 years (OR: 0.91, 95% CI: 0.89, 0.94) mitigated the risk of AMD. Metformin use in women increased the risk of AMD (OR: 1.14, 95% CI: 1.09, 1.18). However, no significant relationship was noticed between metformin use and AMD risk in men (OR: 0.86, 95% CI: 0.73, 1.01). In addition, metformin was associated with a lower risk of AMD in case-control (OR: 0.93, 95% CI: 0.89, 0.97) and cohort (OR: 0.69, 95% CI: 0.51, 0.95) studies. Likewise, metformin use was associated with a lower risk of AMD in the age groups of 50-59 years (OR: 0.54, 95% CI: 0.50, 0.58) and 70-79 years (OR: 0.90, 95% CI: 0.84, 0.97). Conclusion: Metformin administration lowered the risk of AMD by 14%. Moreover, female gender was identified as a risk factor for AMD development. However, further studies are required on this subject to reach a definite conclusion. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (ID: CRD42024539904) and Research Registry (UIN: reviewregistry1824) website. |
| format | Article |
| id | doaj-art-2470407de4ec4a869c4ea36094f7cea8 |
| institution | Kabale University |
| issn | 2345-4202 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropharmacology |
| spelling | doaj-art-2470407de4ec4a869c4ea36094f7cea82024-12-04T06:02:43ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropharmacology2345-42022024-06-01132e12690e1269010.34172/npj.2024.12690npj-12690The relationship between metformin administration and age-related macular degeneration; a systematic review and meta-analysis of observational studiesAbdulateef Abdulkadhium mashaf0Mohammed Abdul-Mounther Othman1Omer Mansib Kassid2Hakim S. Sultan Aljibori3Abdul Amir H kadhum4Ahmed Ali Mohammed5Raed Muslim Mhaibes6General Directorate of Missan Education, Iraqi Ministry of Education, Missan, IraqDepartment of Biochemistry, College of Medicine, Missan University, Missan, IraqCollege of Medicine, University of Missan, 62001 Missan, IraqCollege of Engineering, University of Warith Al-Anbiyaa, Karbala, IraqUniversity of Al-Ameed, Karbala, IraqDental Technology Department, College of Medical Technology, Al-Farahidi University, Baghdad, IraqDepartment of Biochemistry College of Medicine Missan University, Missan IraqIntroduction: Vision loss due to age-related macular degeneration (AMD) is a major and growing health issue. Given that no definitive treatment is available for AMD, this study aims to evaluate the association between metformin use and AMD risk using a systematic review and meta-analysis approach. Materials and Methods: In this study, databases including ProQuest, PubMed, Web of Science, Cochrane, and Google Scholar search engines were searched without time restriction until April 20, 2024, based on PRISMA statement guidelines. Data were analyzed using STATA 14 software at a significance level of P < 0.05. Results: Overall, metformin administration reduced the risk of AMD (OR: 0.86, 95% CI: 0.80, 0.94). Concerning the dosage, a metformin dose of 1-270 g per 2 years (OR: 0.93, 95% CI: 0.90, 0.96) and 271-600 g per 2 years (OR: 0.91, 95% CI: 0.89, 0.94) mitigated the risk of AMD. Metformin use in women increased the risk of AMD (OR: 1.14, 95% CI: 1.09, 1.18). However, no significant relationship was noticed between metformin use and AMD risk in men (OR: 0.86, 95% CI: 0.73, 1.01). In addition, metformin was associated with a lower risk of AMD in case-control (OR: 0.93, 95% CI: 0.89, 0.97) and cohort (OR: 0.69, 95% CI: 0.51, 0.95) studies. Likewise, metformin use was associated with a lower risk of AMD in the age groups of 50-59 years (OR: 0.54, 95% CI: 0.50, 0.58) and 70-79 years (OR: 0.90, 95% CI: 0.84, 0.97). Conclusion: Metformin administration lowered the risk of AMD by 14%. Moreover, female gender was identified as a risk factor for AMD development. However, further studies are required on this subject to reach a definite conclusion. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (ID: CRD42024539904) and Research Registry (UIN: reviewregistry1824) website.https://jnephropharmacology.com/PDF/npj-13-e12690.pdfglucophagemetforminmetformin hydrochloridemacular degenerationage-related macular degeneration |
| spellingShingle | Abdulateef Abdulkadhium mashaf Mohammed Abdul-Mounther Othman Omer Mansib Kassid Hakim S. Sultan Aljibori Abdul Amir H kadhum Ahmed Ali Mohammed Raed Muslim Mhaibes The relationship between metformin administration and age-related macular degeneration; a systematic review and meta-analysis of observational studies Journal of Nephropharmacology glucophage metformin metformin hydrochloride macular degeneration age-related macular degeneration |
| title | The relationship between metformin administration and age-related macular degeneration; a systematic review and meta-analysis of observational studies |
| title_full | The relationship between metformin administration and age-related macular degeneration; a systematic review and meta-analysis of observational studies |
| title_fullStr | The relationship between metformin administration and age-related macular degeneration; a systematic review and meta-analysis of observational studies |
| title_full_unstemmed | The relationship between metformin administration and age-related macular degeneration; a systematic review and meta-analysis of observational studies |
| title_short | The relationship between metformin administration and age-related macular degeneration; a systematic review and meta-analysis of observational studies |
| title_sort | relationship between metformin administration and age related macular degeneration a systematic review and meta analysis of observational studies |
| topic | glucophage metformin metformin hydrochloride macular degeneration age-related macular degeneration |
| url | https://jnephropharmacology.com/PDF/npj-13-e12690.pdf |
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