Characterization of curcumin-loaded nano thermo-sensitive hydrogel
Breast cancer is one of the most common cancers affecting women. Breast cancer therapy is one of the targets of the Sustainable Development Goals (SDGs), namely reducing death rates and ensuring that people receive safe and quality medicines. This research aims to characterize thermosensitive nano h...
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EDP Sciences
2024-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2024/67/bioconf_icobeaf2024_01009.pdf |
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| author | Ikhsanudin Azis Saifullah S Teuku Nanda Zai Khadijah Ari S Bambang |
| author_facet | Ikhsanudin Azis Saifullah S Teuku Nanda Zai Khadijah Ari S Bambang |
| author_sort | Ikhsanudin Azis |
| collection | DOAJ |
| description | Breast cancer is one of the most common cancers affecting women. Breast cancer therapy is one of the targets of the Sustainable Development Goals (SDGs), namely reducing death rates and ensuring that people receive safe and quality medicines. This research aims to characterize thermosensitive nano hydrogel preparations with curcumin as a model drug based on the characteristics of the preparation. Thermosensitive nano hydrogels were formulated with various concentrations of curcumin, namely formulations F1 (10 mg/L), F2 (20 mg/L%), and F3 (40 mg/L). The results showed that the particle size in F I was 472 ± 2.50 nm; F II 423 ± 3.02 nm and F III 455 ± 4.81 nm statistically show a p value <0.05. Data from the zeta potential test results show FI -7.95 ± 1.00 mV, F II -12.47 ± 0.91 mV, and F III -13.33 ± 0.64 mV, with p-value < 0.05 and pH testing shows that F I is 4.73 ± 0.01; FII 4.76 ± 0.01; F III 4.83 ± 0.02, with p-value <0.05. Meanwhile, the stability test of the flask-sensitive hydrogel preparation showed a curcumin F I content of 97.6 ± 0.02%; F II 98.3 ± 0.015%; F III 98.9 ± 0.01%, with p-value <0.05. For the test data, the sol-gel transition time F I was 114 ± 2.08 seconds; F II 112 ± 4.58 seconds; III 154 ± 5.51 seconds with p-value <0.05. F I viscosity data 3,335.98 ± 374.11 cps; F II 2,734.62 ± 428.33 cps; F III 1,923.14 ± 149.86 cps with p value > 0.05. This study concluded that the concentration of poloxamer-407 could reduce particle size, polydispersibility index, zeta potential, and viscosity. |
| format | Article |
| id | doaj-art-24509a8e24514d38a1b918a9f429d48b |
| institution | Kabale University |
| issn | 2117-4458 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-24509a8e24514d38a1b918a9f429d48b2025-01-16T11:19:45ZengEDP SciencesBIO Web of Conferences2117-44582024-01-011480100910.1051/bioconf/202414801009bioconf_icobeaf2024_01009Characterization of curcumin-loaded nano thermo-sensitive hydrogelIkhsanudin Azis0Saifullah S Teuku Nanda1Zai Khadijah2Ari S Bambang3Program Doctoral Faculty of Pharmacy, Universitas Gadjah Mada, YogyakartaProgram Doctoral Faculty of Pharmacy, Universitas Gadjah Mada, YogyakartaProgram Doctoral Faculty of Pharmacy, Universitas Gadjah Mada, YogyakartaProgram Doctoral Faculty of Pharmacy, Universitas Gadjah Mada, YogyakartaBreast cancer is one of the most common cancers affecting women. Breast cancer therapy is one of the targets of the Sustainable Development Goals (SDGs), namely reducing death rates and ensuring that people receive safe and quality medicines. This research aims to characterize thermosensitive nano hydrogel preparations with curcumin as a model drug based on the characteristics of the preparation. Thermosensitive nano hydrogels were formulated with various concentrations of curcumin, namely formulations F1 (10 mg/L), F2 (20 mg/L%), and F3 (40 mg/L). The results showed that the particle size in F I was 472 ± 2.50 nm; F II 423 ± 3.02 nm and F III 455 ± 4.81 nm statistically show a p value <0.05. Data from the zeta potential test results show FI -7.95 ± 1.00 mV, F II -12.47 ± 0.91 mV, and F III -13.33 ± 0.64 mV, with p-value < 0.05 and pH testing shows that F I is 4.73 ± 0.01; FII 4.76 ± 0.01; F III 4.83 ± 0.02, with p-value <0.05. Meanwhile, the stability test of the flask-sensitive hydrogel preparation showed a curcumin F I content of 97.6 ± 0.02%; F II 98.3 ± 0.015%; F III 98.9 ± 0.01%, with p-value <0.05. For the test data, the sol-gel transition time F I was 114 ± 2.08 seconds; F II 112 ± 4.58 seconds; III 154 ± 5.51 seconds with p-value <0.05. F I viscosity data 3,335.98 ± 374.11 cps; F II 2,734.62 ± 428.33 cps; F III 1,923.14 ± 149.86 cps with p value > 0.05. This study concluded that the concentration of poloxamer-407 could reduce particle size, polydispersibility index, zeta potential, and viscosity.https://www.bio-conferences.org/articles/bioconf/pdf/2024/67/bioconf_icobeaf2024_01009.pdf |
| spellingShingle | Ikhsanudin Azis Saifullah S Teuku Nanda Zai Khadijah Ari S Bambang Characterization of curcumin-loaded nano thermo-sensitive hydrogel BIO Web of Conferences |
| title | Characterization of curcumin-loaded nano thermo-sensitive hydrogel |
| title_full | Characterization of curcumin-loaded nano thermo-sensitive hydrogel |
| title_fullStr | Characterization of curcumin-loaded nano thermo-sensitive hydrogel |
| title_full_unstemmed | Characterization of curcumin-loaded nano thermo-sensitive hydrogel |
| title_short | Characterization of curcumin-loaded nano thermo-sensitive hydrogel |
| title_sort | characterization of curcumin loaded nano thermo sensitive hydrogel |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2024/67/bioconf_icobeaf2024_01009.pdf |
| work_keys_str_mv | AT ikhsanudinazis characterizationofcurcuminloadednanothermosensitivehydrogel AT saifullahsteukunanda characterizationofcurcuminloadednanothermosensitivehydrogel AT zaikhadijah characterizationofcurcuminloadednanothermosensitivehydrogel AT arisbambang characterizationofcurcuminloadednanothermosensitivehydrogel |