Alterations of Some Apolipoprotein Levels and ApoE RNA Expression in Iraqi Patients with Chronic Hepatitis B Viral Infection
Background: The high prevalence of hepatitis B virus (HBV) makes it a significant health concern, especially in Iraq. Clinical studies have found that chronic HBV infection affects the occurrence of cardiovascular disease (CVD) by regulating cholesterol metabolism in liver cells. Objective: This stu...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | https://doi.org/10.4103/MJBL.MJBL_1077_23 |
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| author | Amnah Raad Ibrahim Raghad Hassan Hussein Athraa Zaidan Hassan |
| author_facet | Amnah Raad Ibrahim Raghad Hassan Hussein Athraa Zaidan Hassan |
| author_sort | Amnah Raad Ibrahim |
| collection | DOAJ |
| description | Background: The high prevalence of hepatitis B virus (HBV) makes it a significant health concern, especially in Iraq. Clinical studies have found that chronic HBV infection affects the occurrence of cardiovascular disease (CVD) by regulating cholesterol metabolism in liver cells. Objective: This study aimed to determine alterations in some serum lipoproteins (ApoA, ApoB, and apolipoprotein E [ApoE]) and oxidized low-density lipoprotein (OxLDL), as well as ApoE gene expression in Iraqi patients with chronic HBV infection, as potential markers for increased cardiovascular risk. Materials and Methods: This case-control study involved fifty patients with chronic HBV admitted to the Gastroenterology and Hepatology Teaching Hospital in Medical city, Baghdad, besides 40 individuals serving as a healthy control group. Results: The current study showed significantly higher levels of ApoA, ApoB, ApoE, and OxLDL among patients compared to the control group. Additionally, HBV patients demonstrated lower expression of ApoE gene in HBV patients. The receiver operating characteristic curve analysis for all parameters showed high sensitivity and specificity, with area under the curve affirming their potential as biomarkers for increased CVD risk in patients with chronic HBV infection. Conclusion: The study reveals significant disparities in plasma levels of ApoA, ApoB, ApoE, and OxLDL between HBV patients and controls, along with reduced ApoE gene expression in these patients, suggesting a potential role of HBV in apolipoproteins dysfunction. Thus, serum ApoA, ApoB, ApoE, and OxLDL in CHB patients may help identify high-risk patients for CVD, thereby preventing the development of CVD or early diagnosis of (CVD) in these patients. |
| format | Article |
| id | doaj-art-241a00db060e42f895ccb8487085c295 |
| institution | Kabale University |
| issn | 1812-156X 2312-6760 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj-art-241a00db060e42f895ccb8487085c2952025-01-14T11:24:47ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602024-10-0121Suppl 2S266S27110.4103/MJBL.MJBL_1077_23Alterations of Some Apolipoprotein Levels and ApoE RNA Expression in Iraqi Patients with Chronic Hepatitis B Viral InfectionAmnah Raad IbrahimRaghad Hassan HusseinAthraa Zaidan HassanBackground: The high prevalence of hepatitis B virus (HBV) makes it a significant health concern, especially in Iraq. Clinical studies have found that chronic HBV infection affects the occurrence of cardiovascular disease (CVD) by regulating cholesterol metabolism in liver cells. Objective: This study aimed to determine alterations in some serum lipoproteins (ApoA, ApoB, and apolipoprotein E [ApoE]) and oxidized low-density lipoprotein (OxLDL), as well as ApoE gene expression in Iraqi patients with chronic HBV infection, as potential markers for increased cardiovascular risk. Materials and Methods: This case-control study involved fifty patients with chronic HBV admitted to the Gastroenterology and Hepatology Teaching Hospital in Medical city, Baghdad, besides 40 individuals serving as a healthy control group. Results: The current study showed significantly higher levels of ApoA, ApoB, ApoE, and OxLDL among patients compared to the control group. Additionally, HBV patients demonstrated lower expression of ApoE gene in HBV patients. The receiver operating characteristic curve analysis for all parameters showed high sensitivity and specificity, with area under the curve affirming their potential as biomarkers for increased CVD risk in patients with chronic HBV infection. Conclusion: The study reveals significant disparities in plasma levels of ApoA, ApoB, ApoE, and OxLDL between HBV patients and controls, along with reduced ApoE gene expression in these patients, suggesting a potential role of HBV in apolipoproteins dysfunction. Thus, serum ApoA, ApoB, ApoE, and OxLDL in CHB patients may help identify high-risk patients for CVD, thereby preventing the development of CVD or early diagnosis of (CVD) in these patients.https://doi.org/10.4103/MJBL.MJBL_1077_23apoe gene expressionapolipoproteinschronic hbv infection |
| spellingShingle | Amnah Raad Ibrahim Raghad Hassan Hussein Athraa Zaidan Hassan Alterations of Some Apolipoprotein Levels and ApoE RNA Expression in Iraqi Patients with Chronic Hepatitis B Viral Infection Medical Journal of Babylon apoe gene expression apolipoproteins chronic hbv infection |
| title | Alterations of Some Apolipoprotein Levels and ApoE RNA Expression in Iraqi Patients with Chronic Hepatitis B Viral Infection |
| title_full | Alterations of Some Apolipoprotein Levels and ApoE RNA Expression in Iraqi Patients with Chronic Hepatitis B Viral Infection |
| title_fullStr | Alterations of Some Apolipoprotein Levels and ApoE RNA Expression in Iraqi Patients with Chronic Hepatitis B Viral Infection |
| title_full_unstemmed | Alterations of Some Apolipoprotein Levels and ApoE RNA Expression in Iraqi Patients with Chronic Hepatitis B Viral Infection |
| title_short | Alterations of Some Apolipoprotein Levels and ApoE RNA Expression in Iraqi Patients with Chronic Hepatitis B Viral Infection |
| title_sort | alterations of some apolipoprotein levels and apoe rna expression in iraqi patients with chronic hepatitis b viral infection |
| topic | apoe gene expression apolipoproteins chronic hbv infection |
| url | https://doi.org/10.4103/MJBL.MJBL_1077_23 |
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