Green and traditional one-pot synthesis techniques for bioactive quinoline derivatives: A review
The review examines one-pot strategies and their mechanistic approaches for synthesizing the quinoline nucleus from 2009 to 2024, with a focus on their therapeutic potential. The paradigm shifts from conventional synthetic protocols to advanced green methodologies has revolutionized the synthesis of...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | Tetrahedron Green Chem |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773223125000019 |
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| author | Manav C. Parmar Bonny Y. Patel |
| author_facet | Manav C. Parmar Bonny Y. Patel |
| author_sort | Manav C. Parmar |
| collection | DOAJ |
| description | The review examines one-pot strategies and their mechanistic approaches for synthesizing the quinoline nucleus from 2009 to 2024, with a focus on their therapeutic potential. The paradigm shifts from conventional synthetic protocols to advanced green methodologies has revolutionized the synthesis of quinoline derivatives. Strategies that adhere to sustainable chemistry principles by minimizing waste, solvent consumption, and energy input. Various green catalysts, including p-toluenesulfonic acid (p-TSA), para-sulfonic acid calix[4]arene (CX4SO3H), cerium nitrate, ammonium acetate, potassium carbonate (K2CO3), and catalyst-free techniques, have proven effective in synthesizing quinoline analogs. The use of greener solvents such as ethanol and water further supports the eco-friendly synthesis of these compounds. The review also highlights a broad spectrum of pharmacological activities of quinoline derivatives, including antibacterial, antiviral, antidiabetic, anticancer properties and so on. SAR studies show that adding EDGs (-CH3, –OCH3, –OH) and EWGs (-Cl, –F, –NO2, –CF3) can enhance electronic properties, lipophilicity, and receptor-binding affinities. Moreover, hybridization with heterocyclic scaffolds such as furan, pyrazole, indole, and thiadiazole significantly improves bioactivity, demonstrating the intricate relationship between structural modifications and biological efficacy. By merging sustainable chemistry with targeted pharmacological strategies, quinoline-based compounds emerge as innovative candidates for diverse clinical applications. |
| format | Article |
| id | doaj-art-240b90bc2830456bb8c2ac873ebc2f4c |
| institution | Kabale University |
| issn | 2773-2231 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Tetrahedron Green Chem |
| spelling | doaj-art-240b90bc2830456bb8c2ac873ebc2f4c2025-01-05T04:28:54ZengElsevierTetrahedron Green Chem2773-22312025-06-015100062Green and traditional one-pot synthesis techniques for bioactive quinoline derivatives: A reviewManav C. Parmar0Bonny Y. Patel1School of Science, Department of Chemistry, RK University, Rajkot, 360020, Gujarat, IndiaCorresponding author.; School of Science, Department of Chemistry, RK University, Rajkot, 360020, Gujarat, IndiaThe review examines one-pot strategies and their mechanistic approaches for synthesizing the quinoline nucleus from 2009 to 2024, with a focus on their therapeutic potential. The paradigm shifts from conventional synthetic protocols to advanced green methodologies has revolutionized the synthesis of quinoline derivatives. Strategies that adhere to sustainable chemistry principles by minimizing waste, solvent consumption, and energy input. Various green catalysts, including p-toluenesulfonic acid (p-TSA), para-sulfonic acid calix[4]arene (CX4SO3H), cerium nitrate, ammonium acetate, potassium carbonate (K2CO3), and catalyst-free techniques, have proven effective in synthesizing quinoline analogs. The use of greener solvents such as ethanol and water further supports the eco-friendly synthesis of these compounds. The review also highlights a broad spectrum of pharmacological activities of quinoline derivatives, including antibacterial, antiviral, antidiabetic, anticancer properties and so on. SAR studies show that adding EDGs (-CH3, –OCH3, –OH) and EWGs (-Cl, –F, –NO2, –CF3) can enhance electronic properties, lipophilicity, and receptor-binding affinities. Moreover, hybridization with heterocyclic scaffolds such as furan, pyrazole, indole, and thiadiazole significantly improves bioactivity, demonstrating the intricate relationship between structural modifications and biological efficacy. By merging sustainable chemistry with targeted pharmacological strategies, quinoline-based compounds emerge as innovative candidates for diverse clinical applications.http://www.sciencedirect.com/science/article/pii/S2773223125000019QuinolineMulticomponent reactionConventional approachGreen chemistryMicrowave irradiationSolvent free reaction |
| spellingShingle | Manav C. Parmar Bonny Y. Patel Green and traditional one-pot synthesis techniques for bioactive quinoline derivatives: A review Tetrahedron Green Chem Quinoline Multicomponent reaction Conventional approach Green chemistry Microwave irradiation Solvent free reaction |
| title | Green and traditional one-pot synthesis techniques for bioactive quinoline derivatives: A review |
| title_full | Green and traditional one-pot synthesis techniques for bioactive quinoline derivatives: A review |
| title_fullStr | Green and traditional one-pot synthesis techniques for bioactive quinoline derivatives: A review |
| title_full_unstemmed | Green and traditional one-pot synthesis techniques for bioactive quinoline derivatives: A review |
| title_short | Green and traditional one-pot synthesis techniques for bioactive quinoline derivatives: A review |
| title_sort | green and traditional one pot synthesis techniques for bioactive quinoline derivatives a review |
| topic | Quinoline Multicomponent reaction Conventional approach Green chemistry Microwave irradiation Solvent free reaction |
| url | http://www.sciencedirect.com/science/article/pii/S2773223125000019 |
| work_keys_str_mv | AT manavcparmar greenandtraditionalonepotsynthesistechniquesforbioactivequinolinederivativesareview AT bonnyypatel greenandtraditionalonepotsynthesistechniquesforbioactivequinolinederivativesareview |