MECHANISM OF EPIDEMIC PROCESS OF INVASIVE CANDIDIASIS IN HOSPITAL FOR HIV-INFECTED PATIENTS
Aim. To investigate whether contact route is involved in transmission of healthcare-associated invasive candidiasis in HIV-infected patients. Materials and Methods. We performed a prospective epidemiological study to assess the colonization of HIV-infected patients by C. albicans in the hospital env...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Kemerovo State Medical University
2018-06-01
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| Series: | Фундаментальная и клиническая медицина |
| Subjects: | |
| Online Access: | https://fcm.kemsmu.ru/jour/article/view/92 |
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| Summary: | Aim. To investigate whether contact route is involved in transmission of healthcare-associated invasive candidiasis in HIV-infected patients. Materials and Methods. We performed a prospective epidemiological study to assess the colonization of HIV-infected patients by C. albicans in the hospital environment in candidiasis-free and candidiasis-affected locations. We examined 921 clinical samples and 227 samples from hospital facilities. In total, we carried out a microbiology and molecular genetic screening of 70 C. albicans strains. Results. We detected a number of risk factors for invasive candidiasis in HIV-infected patients admitted to the hospital facilities: high level of C. albicans colonization (up to 100%), contamination of the hospital environment (47.3 ± 2.06%), augmented colonization of genitourinary system and gut, increased number of patients with massive colonization of ≥ 2 foci (19.1 ± 1.96% - 57.1 ± 10.8%), and circulation of C. albicans strains with high phospholipase activity. C. albicans strains isolated from these patients shared a similar genetic profile indicative of nosocomial infection. The leading factors of transmission were door and bedside handles, bedside tables and patients’ hands. Conclusion. Contact route is implicated in transmission of nosocomial invasive candidiasis in HIV-positive patients. |
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| ISSN: | 2500-0764 2542-0941 |